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Study Information
Study Attribute Value
CEBS Accession Number: 002-01125-0001-0000-2
Chemical Name: 1-Nitro-2-methylnaphthalene
CASRN: 881-03-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 957464_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Weakly Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/25/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 510 0.495 10.20 25.8 0.000
Test Chemical 1-Nitro-2-methylnaphthalene 
3.5       
 50 1018 468 0.460 9.36 25.8 -7.063 
11.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.01      
 5 105 258 2.457 51.60 25.8 396.728
Trend: -1.145        
Probability: 0.874        

Trial #: 2    Activation: No Activation    Date: 11/15/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1016 458 0.451 9.16 25.8 0.000
Test Chemical 1-Nitro-2-methylnaphthalene 
16         
 50 1022 518 0.507 10.36 32.8 12.436 
18         
 50 1030 532 0.517 10.64 32.8 14.578 
20         
 50 1026 595 0.580 11.90 32.8 28.646
Positive Control Mitomycin-C 
 0.0015    
 50 1020 720 0.706 14.40 25.8 56.589
Mitomycin-C 
 0.01      
 5 103 279 2.709 55.80 25.8 500.890
Trend: 3.939        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 11/30/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1024 444 0.434 8.88 25.5 0.000
Test Chemical 1-Nitro-2-methylnaphthalene 
24.9       
 50 1025 627 0.612 12.54 34.5 41.078 
30         
 50 1013 633 0.625 12.66 34.5 44.116 
35.1       
 50 1021 646 0.633 12.92 34.5 45.923 
40         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1029 631 0.613 12.62 25.5 41.427
Mitomycin-C 
 0.01      
 5 104 179 1.721 35.80 25.5 296.951
Trend: 5.703        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 425 0.412 8.50 25.8 0.000
Test Chemical 1-Nitro-2-methylnaphthalene 
11.7       
 50 1019 553 0.543 11.06 25.8 31.650 
35         
 50 1034 539 0.521 10.78 25.8 26.456 
116.7       
 50 1018 759 0.746 15.18 31.7 80.869 
350         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1032 596 0.578 11.92 25.8 40.099
Cyclophosphamide 
2         
 5 105 176 1.676 35.20 25.8 306.624
Trend: 9.466        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/30/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 20 413 187 0.453 9.35 25.5 0.000
Test Chemical 1-Nitro-2-methylnaphthalene 
25         
 20 414 238 0.575 11.90 34.5 26.965 
37.7       
 20 409 284 0.694 14.20 34.5 53.357 
50         
 20 415 286 0.689 14.30 34.5 52.204 
62.8       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 20 413 286 0.692 14.30 25.5 52.941
Cyclophosphamide 
2         
 5 104 165 1.587 33.00 25.5 250.396
Trend: 4.912        
Probability: 0.000