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Study Information
Study Attribute Value
CEBS Accession Number: 002-01125-0002-0000-3
Chemical Name: 1-Nitro-2-methylnaphthalene
CASRN: 881-03-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 957464_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/22/1983    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1-Nitro-2-methylnaphthalene 
50.4       
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
60         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
70         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
80         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 33 0.330 27.0 23 0.230 22.0 10 0.100 10.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 25 1.000 40.0 6 0.240 20.0 19 0.760 24.0 0 0.000 0.0
Trend: -0.343 0.427 -0.770  
Probability: 0.634 0.335 0.779  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/22/1983    Harvest Time: 21 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: 1-Nitro-2-methylnaphthalene 
20         
 100 4 0.040 4.0 0 0.000 0.0 1 0.010 1.0 3 0.030 3.0 
30         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
40         
 100 6 0.060 4.0 2 0.020 2.0 4 0.040 3.0 0 0.000 0.0 
50.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
12.5       
 100 33 0.330 26.0 11 0.110 11.0 22 0.220 18.0 0 0.000 0.0
Cyclophosphamide 
17.5       
 25 41 1.640 88.0 20 0.800 68.0 21 0.840 60.0 0 0.000 0.0
Trend: -0.635 0.736 -0.267  
Probability: 0.737 0.231 0.605