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Study Information
Study Attribute Value
CEBS Accession Number: 002-01128-0001-0000-5
Chemical Name: 1-Nitronaphthalene
CASRN: 86-57-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 153730_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/18/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 462 0.441 9.24 26.0 0.000
Test Chemical 1-Nitronaphthalene 
1.6       
 50 1048 439 0.419 8.78 26.0 -4.978 
5         
 50 1049 421 0.401 8.42 26.0 -8.961 
16         
 50 1047 475 0.454 9.50 26.0 2.912
Positive Control Mitomycin-C 
 0.005     
 25 521 560 1.075 22.40 26.0 143.820
Trend: 0.237        
Probability: 0.406        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/18/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 473 0.451 9.46 26.0 0.000
Test Chemical 1-Nitronaphthalene 
1.6       
 50 1048 382 0.365 7.64 26.0 -19.162 
5         
 50 1045 329 0.315 6.58 26.0 -30.178 
16         
 50 1049 494 0.471 9.88 26.0 4.440
Positive Control Cyclophosphamide 
1         
 50 1046 895 0.856 17.90 26.0 89.760
Trend: 0.142        
Probability: 0.443