Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01135-0001-0000-3 |
Chemical Name: | 1-Phenyl-2-thiourea |
CASRN: | 103-85-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 575473_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Test Failure |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1041 | 462 | 0.444 | 9.24 | 26.3 | 0.000 |
Test Chemical | 1-Phenyl-2-thiourea | 5.01 | 50 | 1040 | 430 | 0.413 | 8.60 | 26.3 | -6.837 |
17 | 50 | 1041 | 394 | 0.378 | 7.88 | 26.3 | -14.719 | ||
50.11 | 50 | 1035 | 444 | 0.429 | 8.88 | 26.3 | -3.339 | ||
167 | 50 | 1037 | 408 | 0.393 | 8.16 | 30.9 | -11.348 | ||
501.11 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1033 | 522 | 0.505 | 10.44 | 26.3 | 13.862 |
Mitomycin-C | 0.01 | 5 | 107 | 158 | 1.477 | 31.60 | 26.3 | 232.722 | |
Trend: | -1.388 | ||||||||
Probability: | 0.917 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 375 | 0.357 | 7.50 | 26.3 | 0.000 |
Test Chemical | 1-Phenyl-2-thiourea | 167 | 50 | 1046 | 381 | 0.364 | 7.62 | 26.3 | 1.891 |
501.11 | 50 | 1032 | 411 | 0.398 | 8.22 | 26.3 | 11.405 | ||
1700 | 50 | 1041 | 482 | 0.463 | 9.64 | 30.9 | 29.521 | ||
5000 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1047 | 755 | 0.721 | 15.10 | 26.3 | 101.718 |
Cyclophosphamide | 2 | 5 | 102 | 187 | 1.833 | 37.40 | 26.3 | 412.844 | |
Trend: | 4.052 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1041 | 345 | 0.331 | 6.90 | 25.8 | 0.000 |
Test Chemical | 1-Phenyl-2-thiourea | 200 | 50 | 1045 | 527 | 0.504 | 10.54 | 31.0 | 52.169 |
2500 | 50 | 1038 | 449 | 0.433 | 8.98 | 31.0 | 30.521 | ||
3000 | 50 | 1040 | 465 | 0.447 | 9.30 | 31.0 | 34.912 | ||
3500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1049 | 688 | 0.656 | 13.76 | 25.8 | 97.899 |
Cyclophosphamide | 2 | 5 | 105 | 236 | 2.248 | 47.20 | 25.8 | 578.195 | |
Trend: | 2.355 | ||||||||
Probability: | 0.009 |