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Study Information
Study Attribute Value
CEBS Accession Number: 002-01136-0002-0000-5
Chemical Name: 1-Phenyl-3-methyl-5-pyrazolone
CASRN: 89-25-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 837716_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/25/1985    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 1-Phenyl-3-methyl-5-pyrazolone 
746.3       
 200 11 0.055 5.5 6 0.030 3.0 5 0.025 2.5 0 0.000 0.0 
995.3       
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1508         
 200 7 0.035 3.5 3 0.015 1.5 3 0.015 1.5 1 0.005 0.5 
2010         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 17 0.085 7.0 10 0.050 5.0 7 0.035 3.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 12 0.480 44.0 7 0.280 20.0 5 0.200 20.0 0 0.000 0.0
Trend: 0.394 -0.090 0.258  
Probability: 0.347 0.536 0.398  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/29/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 1 0.005 0.5 2 0.010 1.0 1 0.005 0.5
Dimethyl Sulfoxide 
0         
 200 7 0.035 3.0 2 0.010 1.0 5 0.025 2.0 0 0.000 0.0
Test Chemical: 1-Phenyl-3-methyl-5-pyrazolone 
3000         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
4000         
 200 5 0.025 2.5 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0 
5000         
 200 9 0.045 4.0 2 0.010 1.0 6 0.030 3.0 1 0.005 0.5
Positive Control: Cyclophosphamide 
7.5       
 200 28 0.140 11.0 10 0.050 4.5 18 0.090 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 23 0.920 56.0 10 0.400 24.0 13 0.520 44.0 0 0.000 0.0
Trend: 0.525 0.176 0.524  
Probability: 0.300 0.430 0.300