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Study Information
Study Attribute Value
CEBS Accession Number: 002-01141-0002-0000-1
Chemical Name: 1-trans-delta-9-Tetrahydrocannabinol
CASRN: 1972-08-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 829547_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/26/1983    Harvest Time: 22 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: 1-trans-delta-9-Tetrahydrocannabinol 
7.5       
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
10         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
12.5       
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
15         
 28 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
17.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 50 29 0.580 42.0 18 0.360 30.0 11 0.220 20.0 0 0.000 0.0
Trend: -0.222 1.561 -1.323  
Probability: 0.588 0.059 0.907  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/26/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 1-trans-delta-9-Tetrahydrocannabinol 
7.5       
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
10         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
12.5       
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
15         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 50 13 0.260 20.0 6 0.120 8.0 6 0.120 10.0 1 0.020 1.0
Trend: 0.165 0.912 -1.879  
Probability: 0.434 0.181 0.970