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Study Information
Study Attribute Value
CEBS Accession Number: 002-01142-0010-0000-1
Chemical Name: 11-Aminoundecanoic acid
CASRN: 2432-99-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 350805
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 97 129 78 27 23
    98 124 69 24
    82# 104 53 21
    86# 42 48 19
Test Chemical 11-Aminoundecanoic acid 
1.25      
 109 104 99 30 33
    80 101 87 36
  
2.5       
 75 88 70 31 28
    73 117 55 25
  
5         
 76 80 62 27 24
    83 85 53 21
  
10         
 78# 76 37 16 16
    106 86 53 17
  
20         
 80# 90 50 21 29
    77 96 88 38
Positive Control Methyl Methane Sulfonate 
15         
 46 35 195 140 126*
    47 31 156 111

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 109 110 131 40 40
    86# 102 70.5 27
    96 100 136 47
    86 88 116 45
Test Chemical 11-Aminoundecanoic acid 
12         
 99 127 145 49 50
    73 68 113 52
  
14         
 58 65 122 70 70*
    67 70 141 70
  
16         
 35 39 160 155 117*
    49# 62 115.5 79
  
18         
 46 38 143 103 126*
    25 29 112 148
  
20         
 19# 20 123 216 189*
    29 24 143 163
Positive Control Methyl Methane Sulfonate 
15         
 42# 25 444 352 337*
    46 30 440 321

Nonactivation Trial: 3 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Solvent 
 0         
 84 102 136 54 48
    89 94 113 42
    82 109 98 40
    82 95 132 54
Test Chemical 11-Aminoundecanoic acid 
160         
 77 88 107 46 40
    98 101 99 34
  
200         
 73 87 97 44 46
    94 97 136 48
  
240         
 99 99 163 55 50
    91 92 123 45
  
280         
 110 99 169 51 53
    86 89 141 55
  
320         
 86 104 138 53 50
    97 88 133 46
Positive Control Methyl Methane Sulfonate 
15         
 51 32 198 131 131*
    60 32 237 132

Nonactivation Trial: 4 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Solvent 
 0         
 84 105 122 48 44
    104 98 137 44
    100 106 97 32
    70 92 106 51
Test Chemical 11-Aminoundecanoic acid 
160         
 96 104 123 43 41
    95 111 113 40
  
200         
 94 112 171 61 61
    107 111 196 61
  
240         
 78 105 123 52 52
    98 93 155 53
  
280         
 106 99 172 54 55
    91 111 151 55
  
320         
 101 90 160 53 53
    91 97 148 54
Positive Control Methyl Methane Sulfonate 
15         
 63 42 216 115 120*
    57 51 212 124

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Solvent 
 0         
 63 94 126 67 68
    100 109 196 65
    68 99 133 65
    62 98 136 73
Test Chemical 11-Aminoundecanoic acid 
160         
 83 96 176 70 71
    74 84 160 72
  
200         
 68 76 132 64 72
    68 96 164 80
  
240         
 85 97 174 69 68
    74 95 151 68
  
280         
 77 93 139 60 50
    95 96 112 39
  
320         
 71 68 139 65 68
    75 89 157 70
Positive Control 3-Methylcholanthrene 
2.5       
 61 49 608 335 319*
    63 52 567 302

Induced S9 Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Solvent 
 0         
 90 97 72 27 27
    93 90 84 30
    85 105 56 22
    92 109 77 28
Test Chemical 11-Aminoundecanoic acid 
160         
 80 90 64 27 25
    95 98 66 23
  
200         
 90 96 85 31 28
    89 99 68 25
  
240         
 78 90 68 29 29
    101 99 88 29
  
280         
 83 85 73 29 26
    90 103 63 23
  
320         
 88 87 49 18 29
    76 85 89 39
Positive Control 3-Methylcholanthrene 
2.5       
 50 20 262 175 164*
    46 18 208 152

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination