Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01146-0002-0000-6 |
Chemical Name: | 2',3'-Didehydro-3'-deoxythymidine |
CASRN: | 3056-17-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 665471_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
No Activation | 2 | Weakly Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 2.5 | 2 | 0.010 | 1.0 | 4 | 0.020 | 1.5 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 200 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2',3'-Didehydro-3'-deoxythymidine | 889 | 200 | 7 | 0.035 | 3.5 | 2 | 0.010 | 1.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
1333 | 200 | 12 | 0.060 | 4.5 | 3 | 0.015 | 1.5 | 9 | 0.045 | 3.0 | 0 | 0.000 | 0.0 | ||
2000 | 200 | 22 | 0.110 | 9.0 | 1 | 0.005 | 0.5 | 21 | 0.105 | 9.0 | 0 | 0.000 | 0.0 | ||
3000 | 98 | 24 | 0.245 | 20.0 | 1 | 0.010 | 1.0 | 23 | 0.235 | 19.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 12 | 0.480 | 36.0 | 6 | 0.240 | 24.0 | 5 | 0.200 | 16.0 | 1 | 0.040 | 4.0 |
Trend: | 5.512 | -0.256 | 6.148 | ||||||||||||
Probability: | 0.000 | 0.601 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 5 | 0.025 | 2.5 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2',3'-Didehydro-3'-deoxythymidine | 1081 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
2325 | 200 | 9 | 0.045 | 3.5 | 3 | 0.015 | 1.5 | 6 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | ||
5000 | 200 | 18 | 0.090 | 8.0 | 12 | 0.060 | 5.5 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 40 | 1.600 | 76.0 | 23 | 0.920 | 68.0 | 17 | 0.680 | 44.0 | 0 | 0.000 | 0.0 |
Trend: | 3.195 | 2.985 | 1.688 | ||||||||||||
Probability: | 0.001 | 0.001 | 0.046 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 5 | 0.025 | 2.5 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2',3'-Didehydro-3'-deoxythymidine | 503 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1081 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
2325 | 200 | 18 | 0.090 | 8.0 | 3 | 0.015 | 1.5 | 15 | 0.075 | 6.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 32 | 1.280 | 68.0 | 18 | 0.720 | 56.0 | 13 | 0.520 | 36.0 | 1 | 0.040 | 4.0 |
Trend: | 3.312 | -0.509 | 4.292 | ||||||||||||
Probability: | 0.000 | 0.695 | 0.000 |