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Study Information
Study Attribute Value
CEBS Accession Number: 002-01146-0002-0000-6
Chemical Name: 2',3'-Didehydro-3'-deoxythymidine
CASRN: 3056-17-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 665471_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 04/26/1990    Harvest Time: 14.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 2.5 2 0.010 1.0 4 0.020 1.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0
Test Chemical: 2',3'-Didehydro-3'-deoxythymidine 
889         
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0 
1333         
 200 12 0.060 4.5 3 0.015 1.5 9 0.045 3.0 0 0.000 0.0 
2000         
 200 22 0.110 9.0 1 0.005 0.5 21 0.105 9.0 0 0.000 0.0 
3000         
 98 24 0.245 20.0 1 0.010 1.0 23 0.235 19.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 12 0.480 36.0 6 0.240 24.0 5 0.200 16.0 1 0.040 4.0
Trend: 5.512 -0.256 6.148  
Probability: 0.000 0.601 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/27/1990    Harvest Time: 13.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2',3'-Didehydro-3'-deoxythymidine 
1081         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
2325         
 200 9 0.045 3.5 3 0.015 1.5 6 0.030 2.0 0 0.000 0.0 
5000         
 200 18 0.090 8.0 12 0.060 5.5 6 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 40 1.600 76.0 23 0.920 68.0 17 0.680 44.0 0 0.000 0.0
Trend: 3.195 2.985 1.688  
Probability: 0.001 0.001 0.046  


Trial #:2   Activation: No Activation    Date: 02/27/1990    Harvest Time: 14.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.5 4 0.020 2.0 1 0.005 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2',3'-Didehydro-3'-deoxythymidine 
503         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1081         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
2325         
 200 18 0.090 8.0 3 0.015 1.5 15 0.075 6.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 32 1.280 68.0 18 0.720 56.0 13 0.520 36.0 1 0.040 4.0
Trend: 3.312 -0.509 4.292  
Probability: 0.000 0.695 0.000