COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01147-0001-0000-6
Chemical Name: 2',3'-Dideoxyadenosine
CASRN: 4097-22-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 572048_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 05/22/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 403 0.388 8.06 26.0 0.000
Negative (Not Specified) 
0         
 50 1049 421 0.401 8.42 26.0 3.471
Test Chemical 2',3'-Dideoxyadenosine 
6.3       
 50 1046 553 0.529 11.06 26.0 36.303 
21         
 50 1049 711 0.678 14.22 26.0 74.745 
63         
 25 524 508 0.969 20.32 26.0 149.944 
208         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 613 0.584 12.26 26.0 50.516
Mitomycin-C 
 0.004     
 10 210 243 1.157 24.30 26.0 198.330
Trend: 14.419        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/27/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 327 0.312 6.54 26.0 -13.701
Dimethyl Sulfoxide 
0         
 50 1050 380 0.362 7.60 26.0 0.000
Test Chemical 2',3'-Dideoxyadenosine 
21         
 50 1049 634 0.604 12.68 26.0 67.001 
63         
 25 525 455 0.867 18.20 26.0 139.474 
126         
 25 525 538 1.025 21.52 26.0 183.158
Positive Control Mitomycin-C 
 0.001     
 50 1050 507 0.483 10.14 26.0 33.421
Mitomycin-C 
 0.004     
 10 210 220 1.048 22.00 26.0 189.474
Trend: 17.125        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/22/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 447 0.427 8.94 26.0 9.528
Dimethyl Sulfoxide 
0         
 50 1040 405 0.389 8.10 26.0 0.000
Test Chemical 2',3'-Dideoxyadenosine 
63         
 50 1050 648 0.617 12.96 26.0 58.476 
208         
 25 524 458 0.874 18.32 26.0 124.446 
625         
 25 523 466 0.891 18.64 26.0 128.803
Positive Control Cyclophosphamide 
 0.125     
 50 1050 505 0.481 10.10 26.0 23.504
Cyclophosphamide 
 0.5       
 10 210 180 0.857 18.00 26.0 120.106
Trend: 13.771        
Probability: 0.000