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Study Information
Study Attribute Value
CEBS Accession Number: 002-01147-0002-0000-7
Chemical Name: 2',3'-Dideoxyadenosine
CASRN: 4097-22-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 572048_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 06/11/1991    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2',3'-Dideoxyadenosine 
135         
 200 24 0.120 6.0 3 0.015 1.5 21 0.105 4.5 0 0.000 0.0 
291         
 50 67 1.340 44.0 5 0.100 10.0 42 0.840 34.0 20 0.400 4.0 
625         
 50 163 3.260 70.0 6 0.120 12.0 64 1.280 46.0 93 1.860 24.0
Positive Control: Mitomycin-C 
 0.4       
 25 6 0.240 24.0 4 0.160 16.0 2 0.080 8.0 0 0.000 0.0
Trend: 13.594 5.288 10.828  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/11/1991    Harvest Time: 12.7 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2',3'-Dideoxyadenosine 
135         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0 
291         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
625         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 14 0.560 44.0 5 0.200 20.0 9 0.360 28.0 0 0.000 0.0
Trend: 0.853 0.447 0.732  
Probability: 0.197 0.327 0.232  


Trial #:2   Activation: No Activation    Date: 07/23/1991    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 0.5 0 0.000 0.0 4 0.020 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2',3'-Dideoxyadenosine 
135         
 200 15 0.075 7.0 1 0.005 0.5 14 0.070 6.5 0 0.000 0.0 
291         
 50 144 2.880 62.0 2 0.040 4.0 60 1.200 42.0 82 1.640 20.0 
625         
 50 152 3.040 76.0 0 0.000 0.0 64 1.280 44.0 88 1.760 32.0
Positive Control: Mitomycin-C 
 0.4       
 25 14 0.560 44.0 7 0.280 24.0 7 0.280 28.0 0 0.000 0.0
Trend: 14.508 1.414 10.399  
Probability: 0.000 0.079 0.000