COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01148-0002-0000-8
Chemical Name: 2',3'-Dideoxycytidine
CASRN: 7481-89-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 955544_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 02/15/1990    Harvest Time: 13.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2',3'-Dideoxycytidine 
2178         
 100 25 0.250 23.0 2 0.020 2.0 23 0.230 21.0 0 0.000 0.0 
3267         
 50 18 0.360 32.0 3 0.060 6.0 15 0.300 28.0 0 0.000 0.0 
4900         
 100 24 0.240 21.0 4 0.040 3.0 20 0.200 18.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 18 0.720 44.0 10 0.400 28.0 8 0.320 28.0 0 0.000 0.0
Trend: 5.613 1.970 5.213  
Probability: 0.000 0.024 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/19/1990    Harvest Time: 13.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2',3'-Dideoxycytidine 
1060         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
2279         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
4900         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 23 0.920 52.0 11 0.440 44.0 2 0.080 8.0 10 0.400 4.0
Trend: -0.602 -0.259 -0.633  
Probability: 0.726 0.602 0.737  


Trial #:2   Activation: No Activation    Date: 01/19/1990    Harvest Time: 13.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2',3'-Dideoxycytidine 
1060         
 200 17 0.085 8.0 4 0.020 2.0 13 0.065 6.0 0 0.000 0.0 
2279         
 200 24 0.120 8.5 5 0.025 2.0 19 0.095 6.5 0 0.000 0.0 
4900         
 50 20 0.400 32.0 1 0.020 2.0 19 0.380 32.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 24 0.960 52.0 10 0.400 36.0 4 0.160 12.0 10 0.400 4.0
Trend: 6.495 1.634 6.583  
Probability: 0.000 0.051 0.000