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Study Information
Study Attribute Value
CEBS Accession Number: 002-01149-0001-0000-8
Chemical Name: 2',3'-Dideoxyinosine (AIDS Initiative)
CASRN: 69655-05-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 705410_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/04/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 385 0.367 7.70 26.0 0.000
Negative (Not Specified) 
0         
 50 1049 363 0.346 7.26 26.0 -5.804
Test Chemical 2',3'-Dideoxyinosine (AIDS Initiative) 
42         
 50 1049 557 0.531 11.14 26.0 44.537 
125         
 50 1046 676 0.646 13.52 26.0 75.920 
417         
 25 524 470 0.897 18.80 26.0 144.156 
1250         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1047 687 0.656 13.74 26.0 78.612
Mitomycin-C 
 0.004     
 10 208 187 0.899 18.70 26.0 144.725
Trend: 13.542        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/23/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 397 0.378 7.94 26.0 3.385
Dimethyl Sulfoxide 
0         
 50 1049 384 0.366 7.68 26.0 0.000
Test Chemical 2',3'-Dideoxyinosine (AIDS Initiative) 
42         
 50 1049 501 0.478 10.02 26.0 30.469 
125         
 50 1050 632 0.602 12.64 26.0 64.427 
417         
 25 525 489 0.931 19.56 26.0 154.445 
1250         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1051 532 0.506 10.64 26.0 38.278
Mitomycin-C 
 0.004     
 10 210 186 0.886 18.60 26.0 141.957
Trend: 14.212        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/04/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 402 0.385 8.04 26.0 5.587
Dimethyl Sulfoxide 
0         
 50 1042 380 0.365 7.60 26.0 0.000
Test Chemical 2',3'-Dideoxyinosine (AIDS Initiative) 
125         
 50 1051 471 0.448 9.42 26.0 22.886 
417         
 50 1051 641 0.610 12.82 26.0 67.240 
1250         
 50 1049 797 0.760 15.94 26.0 108.337
Positive Control Cyclophosphamide 
 0.125     
 50 1049 670 0.639 13.40 26.0 75.139
Cyclophosphamide 
 0.5       
 10 210 204 0.971 20.40 26.0 166.376
Trend: 13.185        
Probability: 0.000