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Study Information
Study Attribute Value
CEBS Accession Number: 002-01149-0002-0000-9
Chemical Name: 2',3'-Dideoxyinosine (AIDS Initiative)
CASRN: 69655-05-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 705410_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Negative 

Trial #:1   Activation: No Activation    Date: 01/11/1990    Harvest Time: 14.7 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2',3'-Dideoxyinosine (AIDS Initiative) 
270         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
581         
 200 5 0.025 2.5 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0 
1250         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 24 0.960 44.0 9 0.360 32.0 5 0.200 16.0 10 0.400 4.0
Trend: 2.626 1.188 2.566  
Probability: 0.004 0.117 0.005  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/11/1990    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 4 0.020 2.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2',3'-Dideoxyinosine (AIDS Initiative) 
270         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
581         
 200 7 0.035 3.0 5 0.025 2.0 2 0.010 1.0 0 0.000 0.0 
1250         
 200 7 0.035 3.0 6 0.030 2.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 15 0.600 40.0 9 0.360 32.0 6 0.240 12.0 0 0.000 0.0
Trend: 1.493 1.821 0.000  
Probability: 0.068 0.034 0.500  


Trial #:2   Activation: No Activation    Date: 02/15/1990    Harvest Time: 19.7 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2',3'-Dideoxyinosine (AIDS Initiative) 
270         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
581         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0 
1250         
 200 8 0.040 4.0 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 33 1.320 68.0 11 0.440 36.0 12 0.480 44.0 10 0.400 4.0
Trend: 2.485 1.049 2.547  
Probability: 0.006 0.147 0.005