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Study Information
Study Attribute Value
CEBS Accession Number: 002-01167-0001-0000-8
Chemical Name: 2,2-bis(Bromomethyl)-1,3-propanediol
CASRN: 3296-90-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 487287_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 07/07/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 496 0.478 9.92 26.3 0.000
Test Chemical 2,2-bis(Bromomethyl)-1,3-propanediol 
16.7       
 50 1041 485 0.466 9.70 26.3 -2.500 
50         
 50 1042 498 0.478 9.96 26.3 0.018 
167         
 50 1050 545 0.519 10.90 33.5 8.623 
500         
 0 0 0 0.000 0.00 33.5 N/A
Positive Control Mitomycin-C 
 0.005     
 25 519 692 1.333 27.68 26.3 179.032
Trend: 1.429        
Probability: 0.076        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/07/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 415 0.397 8.30 26.3 0.000
Test Chemical 2,2-bis(Bromomethyl)-1,3-propanediol 
500         
 50 1047 462 0.441 9.24 26.3 11.113 
1670         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 25 526 1076 2.046 43.04 26.3 415.104
Trend: 1.559        
Probability: 0.060        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/19/1982    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 496 0.472 9.92 25.5 0.000
Test Chemical 2,2-bis(Bromomethyl)-1,3-propanediol 
800         
 50 1048 556 0.531 11.12 25.5 12.311 
1000         
 50 1047 590 0.564 11.80 25.5 19.292 
1200         
 50 1046 574 0.549 11.48 25.5 16.168
Positive Control Cyclophosphamide 
1.5       
 25 523 840 1.606 33.60 25.5 240.005
Trend: 2.652        
Probability: 0.004