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Study Information
Study Attribute Value
CEBS Accession Number: 002-01167-0002-0000-9
Chemical Name: 2,2-bis(Bromomethyl)-1,3-propanediol
CASRN: 3296-90-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 487287_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 08/10/1982    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,2-bis(Bromomethyl)-1,3-propanediol 
400         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
600         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
700         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.062     
 50 10 0.200 16.0 9 0.180 14.0 1 0.020 2.0 0 0.000 0.0
Trend: -0.964 -1.883 0.007  
Probability: 0.833 0.970 0.497  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/10/1982    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 2 0.020 2.0 2 0.020 2.0
Test Chemical: 2,2-bis(Bromomethyl)-1,3-propanediol 
600         
 100 8 0.080 4.0 2 0.020 1.0 6 0.060 3.0 0 0.000 0.0 
800         
 100 24 0.240 22.0 2 0.020 2.0 20 0.200 18.0 2 0.020 2.0 
1000         
 100 17 0.170 16.0 4 0.040 4.0 13 0.130 13.0 0 0.000 0.0 
1200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 19 0.380 28.0 9 0.180 18.0 9 0.180 14.0 1 0.020 2.0
Trend: 3.686 1.590 3.881  
Probability: 0.000 0.056 0.000