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Study Information
Study Attribute Value
CEBS Accession Number: 002-01170-0001-0000-2
Chemical Name: 2,3,4,5-Tetrachlorophenol
CASRN: 4901-51-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 563610_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/04/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 356 0.347 7.12 26.0 0.000
Test Chemical 2,3,4,5-Tetrachlorophenol 
 0.285     
 50 1022 422 0.413 8.44 26.0 19.003 
 0.95      
 50 1013 472 0.466 9.44 26.0 34.286 
2.85      
 50 1014 481 0.474 9.62 34.0 36.711 
9.5       
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1036 478 0.461 9.56 26.0 32.974
Mitomycin-C 
 0.01      
 5 104 138 1.327 27.60 26.0 282.422
Trend: 4.794        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 01/15/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1013 421 0.416 8.42 25.5 0.000
Test Chemical 2,3,4,5-Tetrachlorophenol 
3         
 50 1026 431 0.420 8.62 25.5 1.078 
4         
 50 1023 467 0.457 9.34 33.7 9.842 
5         
 50 1023 469 0.458 9.38 33.7 10.312 
6         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 578 0.564 11.56 25.5 35.817
Mitomycin-C 
 0.01      
 5 102 177 1.735 35.40 25.5 317.542
Trend: 1.814        
Probability: 0.035        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/04/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 394 0.387 7.88 26.0 0.000
Test Chemical 2,3,4,5-Tetrachlorophenol 
 0.9       
 50 1010 340 0.337 6.80 26.0 -13.022 
2.85      
 50 1023 421 0.412 8.42 26.0 6.331 
9.5       
 50 998 392 0.393 7.84 26.0 1.486 
28.5       
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1028 549 0.534 10.98 26.0 37.985
Cyclophosphamide 
2         
 5 103 179 1.738 35.80 26.0 349.022
Trend: 1.056        
Probability: 0.146