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Study Information
Study Attribute Value
CEBS Accession Number: 002-01171-0001-0000-3
Chemical Name: 2,3,4,6-Tetrachlorophenol
CASRN: 58-90-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 790685_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/19/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 432 0.425 8.64 25.5 0.000
Test Chemical 2,3,4,6-Tetrachlorophenol 
 0.5       
 50 1033 438 0.424 8.76 25.5 -0.182 
1.7       
 50 1016 445 0.438 8.90 25.5 3.111 
5         
 50 1013 443 0.437 8.86 25.5 2.951 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1038 547 0.527 10.94 25.5 24.059
Mitomycin-C 
 0.01      
 5 99 196 1.980 39.20 25.5 366.077
Trend: 0.566        
Probability: 0.286        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/19/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 427 0.411 8.54 25.5 0.000
Test Chemical 2,3,4,6-Tetrachlorophenol 
5         
 50 1031 529 0.513 10.58 25.5 24.729 
16.7       
 50 1036 523 0.505 10.46 25.5 22.719 
50         
 50 1040 542 0.521 10.84 25.5 26.688 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 839 0.811 16.78 25.5 97.057
Cyclophosphamide 
2         
 5 102 211 2.069 42.20 25.5 402.865
Trend: 3.325        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/06/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 451 0.437 9.02 25.5 0.000
Test Chemical 2,3,4,6-Tetrachlorophenol 
50         
 50 1018 434 0.426 8.68 25.5 -2.446 
75         
 50 1030 462 0.449 9.24 25.5 2.638 
100         
 50 1033 476 0.461 9.52 25.5 5.441 
150         
 50 1032 518 0.502 10.36 34.7 14.856
Positive Control Cyclophosphamide 
 0.4       
 50 1021 731 0.716 14.62 25.5 63.831
Cyclophosphamide 
2         
 5 105 263 2.505 52.60 25.5 473.152
Trend: 2.474        
Probability: 0.007