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Study Information
Study Attribute Value
CEBS Accession Number: 002-01171-0002-0000-4
Chemical Name: 2,3,4,6-Tetrachlorophenol
CASRN: 58-90-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 790685_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Weakly Positive* 
Induced Rat Liver S9  2_S9  Weakly Positive* 
Induced Rat Liver S9  3_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/18/1985    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 0.5 0 0.000 0.0
Test Chemical: 2,3,4,6-Tetrachlorophenol 
25         
 200 6 0.030 2.5 0 0.000 0.0 6 0.030 2.5 0 0.000 0.0 
37.5       
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
50         
 200 13 0.065 6.0 3 0.015 1.5 9 0.045 4.5 1 0.005 0.5
Positive Control: Mitomycin-C 
 0.05      
 200 118 0.590 40.5 69 0.345 29.0 49 0.245 21.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 29 1.160 64.0 13 0.520 36.0 16 0.640 48.0 0 0.000 0.0
Trend: 2.576 1.245 2.249  
Probability: 0.005 0.107 0.012  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/02/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2,3,4,6-Tetrachlorophenol 
100         
 200 69 0.345 20.5 32 0.160 10.5 37 0.185 14.5 0 0.000 0.0 
150         
 200 188 0.940 74.0 7 0.035 3.5 161 0.805 71.0 20 0.100 1.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 7 0.035 3.5 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 5 0.200 20.0 4 0.160 16.0 1 0.040 4.0 0 0.000 0.0
Trend: 15.593 0.714 15.819  
Probability: 0.000 0.238 0.000  


Trial #:2   Activation: No Activation    Date: 01/24/1986    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,3,4,6-Tetrachlorophenol 
40         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0 
50         
 100 5 0.050 5.0 1 0.010 1.0 2 0.020 2.0 2 0.020 2.0 
125         
 25 30 1.200 64.0 0 0.000 0.0 30 1.200 64.0 0 0.000 0.0 
250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 32 0.320 25.0 12 0.120 11.0 20 0.200 16.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 13 0.520 36.0 7 0.280 24.0 6 0.240 20.0 0 0.000 0.0
Trend: 8.357 -0.481 8.939  
Probability: 0.000 0.685 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/14/1986    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,3,4,6-Tetrachlorophenol 
50         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
100         
 200 144 0.720 53.0 26 0.130 11.0 118 0.590 48.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 12 0.060 6.0 4 0.020 2.0 8 0.040 4.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 7 0.280 24.0 4 0.160 16.0 3 0.120 8.0 0 0.000 0.0
Trend: 15.648 6.187 15.071  
Probability: 0.000 0.000 0.000  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 01/21/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2,3,4,6-Tetrachlorophenol 
125         
 25 13 0.520 40.0 0 0.000 0.0 12 0.480 36.0 1 0.040 4.0 
150         
 25 18 0.720 68.0 0 0.000 0.0 18 0.720 68.0 0 0.000 0.0 
175         
 25 16 0.640 52.0 1 0.040 4.0 15 0.600 52.0 0 0.000 0.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 15 0.150 13.0 9 0.090 8.0 6 0.060 6.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 22 0.880 48.0 13 0.520 40.0 9 0.360 28.0 0 0.000 0.0
Trend: 7.225 0.804 7.465  
Probability: 0.000 0.211 0.000