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Study Information
Study Attribute Value
CEBS Accession Number: 002-01173-0001-0000-5
Chemical Name: 2,3,4-Trichlorophenol
CASRN: 15950-66-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 200212_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 10/30/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1011 407 0.403 8.14 25.6 0.000
Test Chemical 2,3,4-Trichlorophenol 
 0.2       
 50 1005 474 0.472 9.48 33.1 17.157 
 0.5       
 50 1014 438 0.432 8.76 33.1 7.298 
1.7       
 0 0 0 0.000 0.00 33.1 N/A 
5         
 50 1003 456 0.455 9.12 33.1 12.933 
16.7       
 0 0 0 0.000 0.00 33.1 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1022 552 0.540 11.04 25.6 34.167
Mitomycin-C 
 0.01      
 5 103 155 1.505 31.00 25.6 273.810
Trend: 1.214        
Probability: 0.112        

Trial #: 2    Activation: No Activation    Date: 11/19/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 400 0.389 8.00 25.6 0.000
Test Chemical 2,3,4-Trichlorophenol 
 0.5       
 50 1031 416 0.403 8.32 25.6 3.697 
1.7       
 50 1020 387 0.379 7.74 25.6 -2.491 
5         
 50 1017 424 0.417 8.48 31.4 7.147 
16.8       
 0 0 0 0.000 0.00 31.4 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1030 625 0.607 12.50 25.6 55.947
Mitomycin-C 
 0.01      
 5 104 234 2.250 46.80 25.6 478.250
Trend: 0.641        
Probability: 0.261        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/30/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 397 0.390 7.94 26.6 0.000
Test Chemical 2,3,4-Trichlorophenol 
5         
 50 1011 435 0.430 8.70 26.6 10.222 
16.7       
 50 1015 489 0.482 9.78 26.6 23.417 
50         
 50 1021 552 0.541 11.04 26.6 38.498 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1009 628 0.622 12.56 26.6 59.441
Cyclophosphamide 
2         
 5 103 152 1.476 30.40 26.6 278.039
Trend: 5.274        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/19/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1024 419 0.409 8.38 25.6 0.000
Test Chemical 2,3,4-Trichlorophenol 
15         
 50 1019 459 0.450 9.18 25.6 10.084 
37.5       
 50 1006 493 0.490 9.86 25.6 19.766 
75         
 50 1010 517 0.512 10.34 31.4 25.099 
112.5       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1011 654 0.647 13.08 25.6 58.093
Cyclophosphamide 
2         
 5 104 162 1.558 32.40 25.6 280.687
Trend: 3.636        
Probability: 0.000