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Study Information
Study Attribute Value
CEBS Accession Number: 002-01173-0002-0000-6
Chemical Name: 2,3,4-Trichlorophenol
CASRN: 15950-66-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 200212_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 12/12/1985    Harvest Time: 20 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,3,4-Trichlorophenol 
11.3       
 200 4 0.020 2.0 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 
15.1       
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
37.7       
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
75.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 57 0.285 22.0 31 0.155 14.5 26 0.130 11.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 23 0.920 40.0 10 0.400 28.0 13 0.520 36.0 0 0.000 0.0
Trend: 0.240 0.479 0.056  
Probability: 0.405 0.316 0.478  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/12/1985    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,3,4-Trichlorophenol 
12.1       
 200 10 0.050 2.5 4 0.020 1.0 6 0.030 2.0 0 0.000 0.0 
30.2       
 200 6 0.030 2.0 4 0.020 1.0 2 0.010 1.0 0 0.000 0.0 
60.3       
 200 18 0.090 5.5 4 0.020 2.0 14 0.070 5.5 0 0.000 0.0 
90.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 15 0.075 6.0 4 0.020 1.5 11 0.055 5.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 13 0.520 28.0 2 0.080 8.0 11 0.440 28.0 0 0.000 0.0
Trend: 2.445 0.839 3.288  
Probability: 0.007 0.201 0.001  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/16/1986    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 2,3,4-Trichlorophenol 
49.8       
 100 9 0.090 5.0 1 0.010 1.0 8 0.080 5.0 0 0.000 0.0 
60         
 100 25 0.250 10.0 3 0.030 2.0 12 0.120 7.0 10 0.100 1.0 
70.2       
 25 17 0.680 44.0 9 0.360 28.0 8 0.320 28.0 0 0.000 0.0 
80         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 13 0.130 11.0 2 0.020 2.0 11 0.110 9.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 6 0.240 24.0 3 0.120 12.0 3 0.120 12.0 0 0.000 0.0
Trend: 4.986 4.812 3.357  
Probability: 0.000 0.000 0.000