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Study Information
Study Attribute Value
CEBS Accession Number: 002-01175-0001-0000-7
Chemical Name: 2,3,5,6-Tetrachloronitrobenzene
CASRN: 117-18-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 915939_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/07/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 413 0.393 8.26 26.0 0.000
Test Chemical 2,3,5,6-Tetrachloronitrobenzene 
1         
 50 1046 485 0.464 9.70 26.0 17.882 
3         
 50 1048 473 0.451 9.46 26.0 14.746 
10         
 50 1050 543 0.517 10.86 26.0 31.477
Positive Control Triethylenemelamine 
 0.015     
 50 1051 1506 1.433 30.12 26.0 264.302
Trend: 3.875        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/07/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 474 0.452 9.48 26.0 0.000
Test Chemical 2,3,5,6-Tetrachloronitrobenzene 
1         
 50 1050 489 0.466 9.78 26.0 3.066 
3         
 50 1048 476 0.454 9.52 26.0 0.518 
10         
 50 1050 508 0.484 10.16 26.0 7.071 
30         
 50 1048 552 0.527 11.04 28.0 16.567
Positive Control Cyclophosphamide 
1         
 50 1049 1114 1.062 22.28 26.0 135.021
Trend: 2.495        
Probability: 0.006