Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01176-0001-0000-8 |
Chemical Name: | 2,3,5,6-Tetrachlorophenol |
CASRN: | 935-95-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 707071_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
Induced Rat Liver S9 | 2_S9 | Weakly Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1018 | 386 | 0.379 | 7.72 | 25.5 | 0.000 |
Test Chemical | 2,3,5,6-Tetrachlorophenol | 0.5 | 50 | 1010 | 402 | 0.398 | 8.04 | 31.0 | 4.970 |
1.7 | 50 | 1006 | 481 | 0.478 | 9.62 | 31.0 | 26.098 | ||
5 | 50 | 1002 | 456 | 0.455 | 9.12 | 31.0 | 20.021 | ||
16.7 | 0 | 0 | 0 | 0.000 | 0.00 | 31.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1021 | 606 | 0.594 | 12.12 | 25.5 | 56.534 |
Mitomycin-C | 0.01 | 5 | 102 | 174 | 1.706 | 34.80 | 25.5 | 349.893 | |
Trend: | 3.397 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1015 | 378 | 0.372 | 7.56 | 25.3 | 0.000 |
Test Chemical | 2,3,5,6-Tetrachlorophenol | 5 | 50 | 1024 | 405 | 0.396 | 8.10 | 25.3 | 6.201 |
10 | 50 | 1023 | 478 | 0.467 | 9.56 | 32.2 | 25.466 | ||
15.1 | 50 | 1030 | 467 | 0.453 | 9.34 | 32.2 | 21.746 | ||
20.4 | 0 | 0 | 0 | 0.000 | 0.00 | 32.2 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1018 | 522 | 0.513 | 10.44 | 25.3 | 37.688 |
Mitomycin-C | 0.01 | 5 | 103 | 184 | 1.786 | 36.80 | 25.3 | 379.684 | |
Trend: | 3.601 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1020 | 391 | 0.383 | 7.82 | 25.5 | 0.000 |
Test Chemical | 2,3,5,6-Tetrachlorophenol | 16.7 | 50 | 1013 | 445 | 0.439 | 8.90 | 25.5 | 14.597 |
50 | 50 | 1010 | 393 | 0.389 | 7.86 | 25.5 | 1.507 | ||
166.7 | 50 | 1021 | 496 | 0.486 | 9.92 | 31.0 | 26.730 | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1005 | 594 | 0.591 | 11.88 | 25.5 | 54.186 |
Cyclophosphamide | 2 | 5 | 104 | 244 | 2.346 | 48.80 | 25.5 | 512.040 | |
Trend: | 2.875 | ||||||||
Probability: | 0.002 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1016 | 389 | 0.383 | 7.78 | 25.5 | 0.000 |
Test Chemical | 2,3,5,6-Tetrachlorophenol | 75.4 | 50 | 1025 | 466 | 0.455 | 9.32 | 31.0 | 18.742 |
150.8 | 50 | 1024 | 395 | 0.386 | 7.90 | 31.0 | 0.749 | ||
225 | 50 | 1023 | 496 | 0.485 | 9.92 | 31.0 | 26.634 | ||
300 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1032 | 590 | 0.572 | 11.80 | 25.5 | 49.319 |
Cyclophosphamide | 2 | 5 | 102 | 188 | 1.843 | 37.60 | 25.5 | 381.395 | |
Trend: | 2.226 | ||||||||
Probability: | 0.013 |