Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01176-0002-0000-9 |
Chemical Name: | 2,3,5,6-Tetrachlorophenol |
CASRN: | 935-95-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 707071_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 5 | 0.025 | 2.5 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 6 | 0.030 | 3.0 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2,3,5,6-Tetrachlorophenol | 14.8 | 200 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
37.3 | 200 | 9 | 0.045 | 3.5 | 1 | 0.005 | 0.5 | 8 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | ||
75 | 71 | 5 | 0.070 | 5.6 | 0 | 0.000 | 0.0 | 5 | 0.070 | 5.6 | 0 | 0.000 | 0.0 | ||
112 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 83 | 0.415 | 21.0 | 30 | 0.150 | 11.5 | 43 | 0.215 | 13.5 | 10 | 0.050 | 0.5 |
Mitomycin-C | 0.08 | 25 | 30 | 1.200 | 68.0 | 10 | 0.400 | 32.0 | 20 | 0.800 | 44.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.153 | -0.953 | 1.881 | ||||||||||||
Probability: | 0.125 | 0.830 | 0.030 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2,3,5,6-Tetrachlorophenol | 149.1 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
198.7 | 25 | 15 | 0.600 | 24.0 | 7 | 0.280 | 12.0 | 8 | 0.320 | 20.0 | 0 | 0.000 | 0.0 | ||
248.5 | 25 | 31 | 1.240 | 48.0 | 13 | 0.520 | 28.0 | 18 | 0.720 | 44.0 | 0 | 0.000 | 0.0 | ||
301 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 6.25 | 100 | 13 | 0.130 | 10.0 | 4 | 0.040 | 4.0 | 9 | 0.090 | 6.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 9 | 0.360 | 36.0 | 2 | 0.080 | 8.0 | 7 | 0.280 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | 7.773 | 6.236 | 7.305 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 1.5 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | 2,3,5,6-Tetrachlorophenol | 86.8 | 200 | 6 | 0.030 | 3.0 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
175 | 25 | 27 | 1.080 | 28.0 | 5 | 0.200 | 12.0 | 12 | 0.480 | 16.0 | 10 | 0.400 | 4.0 | ||
262.5 | 10 | 59 | 5.900 | 80.0 | 2 | 0.200 | 10.0 | 7 | 0.700 | 30.0 | 50 | 5.000 | 50.0 | ||
350 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 6.25 | 200 | 13 | 0.065 | 5.5 | 3 | 0.015 | 1.5 | 10 | 0.050 | 4.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 8 | 0.320 | 28.0 | 5 | 0.200 | 20.0 | 3 | 0.120 | 8.0 | 0 | 0.000 | 0.0 | |
Trend: | 9.137 | 3.454 | 5.396 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |