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Study Information
Study Attribute Value
CEBS Accession Number: 002-01176-0002-0000-9
Chemical Name: 2,3,5,6-Tetrachlorophenol
CASRN: 935-95-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 707071_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 01/28/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 3 0.015 1.5 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 2,3,5,6-Tetrachlorophenol 
14.8       
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
37.3       
 200 9 0.045 3.5 1 0.005 0.5 8 0.040 3.0 0 0.000 0.0 
75         
 71 5 0.070 5.6 0 0.000 0.0 5 0.070 5.6 0 0.000 0.0 
112         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 83 0.415 21.0 30 0.150 11.5 43 0.215 13.5 10 0.050 0.5
Mitomycin-C 
 0.08      
 25 30 1.200 68.0 10 0.400 32.0 20 0.800 44.0 0 0.000 0.0
Trend: 1.153 -0.953 1.881  
Probability: 0.125 0.830 0.030  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/18/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2,3,5,6-Tetrachlorophenol 
149.1       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
198.7       
 25 15 0.600 24.0 7 0.280 12.0 8 0.320 20.0 0 0.000 0.0 
248.5       
 25 31 1.240 48.0 13 0.520 28.0 18 0.720 44.0 0 0.000 0.0 
301         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 13 0.130 10.0 4 0.040 4.0 9 0.090 6.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 9 0.360 36.0 2 0.080 8.0 7 0.280 28.0 0 0.000 0.0
Trend: 7.773 6.236 7.305  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/28/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 1.5 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2,3,5,6-Tetrachlorophenol 
86.8       
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0 
175         
 25 27 1.080 28.0 5 0.200 12.0 12 0.480 16.0 10 0.400 4.0 
262.5       
 10 59 5.900 80.0 2 0.200 10.0 7 0.700 30.0 50 5.000 50.0 
350         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 13 0.065 5.5 3 0.015 1.5 10 0.050 4.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 8 0.320 28.0 5 0.200 20.0 3 0.120 8.0 0 0.000 0.0
Trend: 9.137 3.454 5.396  
Probability: 0.000 0.000 0.000