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Study Information
Study Attribute Value
CEBS Accession Number: 002-01178-0001-0000-0
Chemical Name: 2,3,6-Trichlorophenol
CASRN: 933-75-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 048907_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/22/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 391 0.381 7.82 26.4 0.000
Test Chemical 2,3,6-Trichlorophenol 
 0.5       
 50 1005 372 0.370 7.44 26.4 -2.966 
1.7       
 50 1019 450 0.442 9.00 26.4 15.767 
5         
 50 988 411 0.416 8.22 26.4 9.052 
16.7       
 0 0 0 0.000 0.00 31.9 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1011 534 0.528 10.68 26.4 38.464
Mitomycin-C 
 0.01      
 5 106 168 1.585 33.60 26.4 315.480
Trend: 2.007        
Probability: 0.022        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/22/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 359 0.353 7.18 26.4 0.000
Test Chemical 2,3,6-Trichlorophenol 
50         
 50 1022 423 0.414 8.46 26.4 17.251 
166.7       
 50 1010 372 0.368 7.44 26.4 4.339 
500         
 50 1013 401 0.396 8.02 26.4 12.140 
1666.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1016 642 0.632 12.84 26.4 79.006
Cyclophosphamide 
2         
 5 104 261 2.510 52.20 26.4 610.941
Trend: 0.941        
Probability: 0.173