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Study Information
Study Attribute Value
CEBS Accession Number: 002-01178-0002-0000-1
Chemical Name: 2,3,6-Trichlorophenol
CASRN: 933-75-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 048907_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 11/07/1985    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 5 0.025 1.5 2 0.010 1.0 3 0.015 0.5 0 0.000 0.0
Test Chemical: 2,3,6-Trichlorophenol 
37.1       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
50.4       
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0 
126         
 117 12 0.103 6.0 2 0.017 1.7 10 0.085 5.1 0 0.000 0.0 
252         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 67 0.335 23.0 19 0.095 9.0 48 0.240 16.5 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 21 0.840 48.0 10 0.400 28.0 11 0.440 28.0 0 0.000 0.0
Trend: 2.839 0.599 3.403  
Probability: 0.002 0.274 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/04/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2,3,6-Trichlorophenol 
251.3       
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
502.5       
 25 59 2.360 64.0 17 0.680 36.0 12 0.480 28.0 30 1.200 12.0 
750         
 25 140 5.600 84.0 9 0.360 8.0 21 0.840 40.0 110 4.400 44.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 14 0.140 11.0 6 0.060 5.0 8 0.080 8.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 10 0.400 28.0 1 0.040 4.0 9 0.360 28.0 0 0.000 0.0
Trend: 11.132 5.000 6.660  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 02/18/1985    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 7 0.035 2.0 0 0.000 0.0 7 0.035 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2,3,6-Trichlorophenol 
124.3       
 200 9 0.045 4.0 1 0.005 0.5 8 0.040 3.5 0 0.000 0.0 
175         
 200 16 0.080 7.0 0 0.000 0.0 16 0.080 7.0 0 0.000 0.0 
250         
 200 15 0.075 6.5 1 0.005 0.5 14 0.070 6.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 51 0.255 20.5 21 0.105 10.0 30 0.150 12.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 13 0.520 40.0 8 0.320 32.0 5 0.200 20.0 0 0.000 0.0
Trend: 2.668 -0.251 2.849  
Probability: 0.004 0.599 0.002  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 11/07/1985    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2,3,6-Trichlorophenol 
150         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0 
375         
 200 44 0.220 10.0 16 0.080 4.5 28 0.140 8.0 0 0.000 0.0 
750         
 25 64 2.560 68.0 1 0.040 4.0 13 0.520 48.0 50 2.000 20.0 
1125         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 24 0.120 8.5 6 0.030 3.0 18 0.090 7.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 12 0.480 40.0 1 0.040 4.0 10 0.400 36.0 1 0.040 4.0
Trend: 8.421 2.500 7.709  
Probability: 0.000 0.006 0.000