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Study Information
Study Attribute Value
CEBS Accession Number: 002-01179-0022-0000-4
Chemical Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 1746-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 163229_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/01/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0942
Test Group Dose
(ug/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 13.00 ± 0.85 0.0000
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
250         
 8 8.50 ± 1.12 0.0165
  
500         
 7 10.00 ± 1.57 0.0028
  
1000         
 8 7.75 ± 1.44 0.0398
Vehicle Control No Stressor 
 0         
 8 4.75 ± 0.84 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/20/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.9055
Test Group Dose
(ug/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 28.25 ± 2.19 0.0000
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
250         
 8 1.75 ± 0.70 0.6932
  
500         
 8 0.50 ± 0.33 0.9832
  
1000         
 8 1.25 ± 0.37 0.8596
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.88 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/11/91 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2532
Test Group Dose
(ug/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 8.25 ± 1.67 0.0000
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
250         
 8 2.75 ± 0.65 0.0649
  
500         
 8 2.50 ± 0.73 0.0962
  
1000         
 8 2.25 ± 0.70 0.1404
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed