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Study Information
Study Attribute Value
CEBS Accession Number: 002-01182-0001-0000-5
Chemical Name: 2,3-Dibromo-1-propanol
CASRN: 96-13-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 390611_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/04/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 449 0.428 8.98 25.6 0.000
Test Chemical 2,3-Dibromo-1-propanol 
50.9       
 50 1047 727 0.694 14.54 25.6 62.225 
169.6       
 10 210 352 1.676 35.20 25.6 291.609 
508.8       
 10 209 394 1.885 39.40 31.4 340.432 
1700         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 558 0.534 11.16 25.6 24.752
Mitomycin-C 
 0.01      
 5 104 197 1.894 39.40 25.6 342.550
Trend: 25.790        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/25/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 526 245 0.466 9.80 25.9 0.000
Test Chemical 2,3-Dibromo-1-propanol 
110.7       
 25 529 696 1.316 27.84 25.9 182.471 
169.9       
 10 205 374 1.824 37.40 25.9 291.685 
253.6       
 5 105 230 2.190 46.00 25.9 370.282 
507.1       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 520 249 0.479 9.96 25.9 2.805
Mitomycin-C 
 0.01      
 5 107 176 1.645 35.20 25.9 253.141
Trend: 20.109        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/04/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 412 0.393 8.24 25.6 0.000
Test Chemical 2,3-Dibromo-1-propanol 
50.9       
 50 1047 521 0.498 10.42 25.6 26.577 
169.6       
 50 1049 784 0.747 15.68 25.6 90.110 
508.8       
 50 1050 1154 1.099 23.08 25.6 179.564 
1700         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1049 465 0.443 9.30 25.6 12.756
Cyclophosphamide 
2         
 5 104 109 1.048 21.80 25.6 166.598
Trend: 20.660        
Probability: 0.000