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Study Information
Study Attribute Value
CEBS Accession Number: 002-01182-0002-0000-6
Chemical Name: 2,3-Dibromo-1-propanol
CASRN: 96-13-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 390611_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 03/12/1987    Harvest Time: 20.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2,3-Dibromo-1-propanol 
626.4       
 200 36 0.180 16.5 7 0.035 3.5 29 0.145 13.5 0 0.000 0.0 
1252.8       
 50 23 0.460 36.0 1 0.020 2.0 22 0.440 34.0 0 0.000 0.0 
1869.8       
 10 22 2.200 80.0 0 0.000 0.0 22 2.200 80.0 0 0.000 0.0 
2493.1       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 119 0.595 37.0 43 0.215 20.0 66 0.330 24.5 10 0.050 0.5
Mitomycin-C 
 0.08      
 25 35 1.400 56.0 11 0.440 32.0 14 0.560 36.0 10 0.400 4.0
Trend: 9.281 1.338 9.278  
Probability: 0.000 0.090 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/20/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 2 0.010 1.0 3 0.015 1.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 0.5 0 0.000 0.0
Test Chemical: 2,3-Dibromo-1-propanol 
626.4       
 200 45 0.225 12.5 14 0.070 5.5 21 0.105 7.5 10 0.050 0.5 
1252.8       
 50 22 0.440 34.0 6 0.120 12.0 15 0.300 24.0 1 0.020 2.0 
1869.8       
 25 17 0.680 48.0 0 0.000 0.0 15 0.600 44.0 2 0.080 8.0 
2493.1       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 29 0.145 13.5 4 0.020 2.0 25 0.125 12.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 20 0.800 40.0 5 0.200 20.0 15 0.600 24.0 0 0.000 0.0
Trend: 8.787 2.608 8.381  
Probability: 0.000 0.005 0.000  


Trial #:2   Activation: No Activation    Date: 04/16/1987    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 3.0 2 0.020 2.0 2 0.020 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2,3-Dibromo-1-propanol 
620.6       
 100 16 0.160 15.0 6 0.060 6.0 9 0.090 8.0 1 0.010 1.0 
1241.1       
 50 20 0.400 32.0 1 0.020 2.0 19 0.380 30.0 0 0.000 0.0 
1880.5       
 10 15 1.500 90.0 1 0.100 10.0 14 1.400 80.0 0 0.000 0.0 
2238.7       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 100 20 0.200 17.0 8 0.080 8.0 12 0.120 10.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 20 0.800 60.0 7 0.280 24.0 13 0.520 36.0 0 0.000 0.0
Trend: 6.807 0.264 7.612  
Probability: 0.000 0.396 0.000