Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01182-0011-0000-6
Chemical Name: 2,3-Dibromo-1-propanol
CASRN: 96-13-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 512622
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 91# 86 120 44 43
    92 90 133 48
    91 99 116 43
    108 125 116 36
Test Chemical 2,3-Dibromo-1-propanol 
 0.0625    
 106 81 179 56 50
    103 83 159 52
    108 89 137 42
  
 0.125     
 120 74 232 65 69*
    108 84 234 72
    131r 76 217 55
  
 0.25      
 104 45 405 129 121*
    109 53 329 101
    92 44 365 133
  
 0.375     
 96 24 634 220 215*
    79 29 529 222
    81 20 493 202
  
 0.5       
 70 9 628 300 235*
    99 32 503 170
    126r 35 452 120
  
 0.75      
   
   
Positive Control Methyl Methane Sulfonate 
5         
 62 48 548 294 297*
    50 25 543 361
    76 50 539 236

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 64 90 91 47 39
    74 91 93 42
    59 88 65 37
    86 131 81 31
Test Chemical 2,3-Dibromo-1-propanol 
 0.0625    
 89 96 144 54 88*
    74 87 142 64
    65 45 284 145
  
 0.125     
 74 59 268 120 116*
    81 68 300 124
    82 82 254 103
  
 0.25      
 85 62 498 195 200*
    79 47 558 236
    85 59 428 169
  
 0.375     
 60 17 753 417 428*
    60 26 710 392
    55 16 780 476
  
 0.5       
 42 5 669 527 525*
    47 13 687 492
    41 6 681 556
  
 0.75      
   
  
1         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 72 64 564 262 303*
    53 58 559 354
    61 56 541 294

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination