Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01182-0011-0000-6
Chemical Name:	2,3-Dibromo-1-propanol
CASRN:	96-13-9
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	512622
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. uL/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	91#	86	120	44	43
			92	90	133	48
			91	99	116	43
			108	125	116	36
Test Chemical	2,3-Dibromo-1-propanol	0.0625	106	81	179	56	50
			103	83	159	52
			108	89	137	42
		0.125	120	74	232	65	69*
			108	84	234	72
			131r	76	217	55
		0.25	104	45	405	129	121*
			109	53	329	101
			92	44	365	133
		0.375	96	24	634	220	215*
			79	29	529	222
			81	20	493	202
		0.5	70	9	628	300	235*
			99	32	503	170
			126r	35	452	120
		0.75


Positive Control	Methyl Methane Sulfonate	5	62	48	548	294	297*
			50	25	543	361
			76	50	539	236

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. uL/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	64	90	91	47	39
			74	91	93	42
			59	88	65	37
			86	131	81	31
Test Chemical	2,3-Dibromo-1-propanol	0.0625	89	96	144	54	88*
			74	87	142	64
			65	45	284	145
		0.125	74	59	268	120	116*
			81	68	300	124
			82	82	254	103
		0.25	85	62	498	195	200*
			79	47	558	236
			85	59	428	169
		0.375	60	17	753	417	428*
			60	26	710	392
			55	16	780	476
		0.5	42	5	669	527	525*
			47	13	687	492
			41	6	681	556
		0.75

		1


Positive Control	Methyl Methane Sulfonate	5	72	64	564	262	303*
			53	58	559	354
			61	56	541	294

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination