COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01190-0001-0000-4
Chemical Name: 2,3-Dichloropropylene
CASRN: 78-88-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 850916_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 01/14/1986    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1043 403 0.386 8.06 26.5 0.000
Test Chemical 2,3-Dichloropropylene
5.05      
50 1045 391 0.374 7.82 26.5 -3.163
15.2       
50 1055 605 0.573 12.10 26.5 48.416
50.5       
50 1050 1111 1.058 22.22 26.6 173.844
152         
0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C
 0.002     
50 1049 711 0.678 14.22 26.5 75.418
Mitomycin-C
 0.01      
10 210 241 1.148 24.10 26.5 197.014
Trend: 20.858        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/04/1986    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1021 356 0.349 7.12 26.0 0.000
Test Chemical 2,3-Dichloropropylene
9.95      
50 1049 541 0.516 10.82 26.0 47.910
29.9       
50 1052 839 0.798 16.78 26.0 128.729
49.8       
50 1060 1111 1.048 22.22 30.0 200.597
74.5       
0 0 0 0.000 0.00 30.0 N/A
Positive Control Mitomycin-C
 0.002     
50 1033 510 0.494 10.20 26.0 41.594
Mitomycin-C
 0.01      
10 209 201 0.962 20.10 26.0 175.820
Trend: 20.734        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/14/1986    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1040 482 0.463 9.64 26.0 0.000
Test Chemical 2,3-Dichloropropylene
5.05      
50 1040 451 0.434 9.02 26.0 -6.432
15.2       
50 1038 492 0.474 9.84 26.0 2.271
50.5       
50 1042 789 0.757 15.78 26.0 63.379
152         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.5       
50 1044 690 0.661 13.80 26.0 42.605
Cyclophosphamide
2.5       
10 210 329 1.567 32.90 26.0 238.036
Trend: 9.227        
Probability: 0.000