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Study Information
Study Attribute Value
CEBS Accession Number: 002-01190-0001-0000-4
Chemical Name: 2,3-Dichloropropylene
CASRN: 78-88-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 850916_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 01/14/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 403 0.386 8.06 26.5 0.000
Test Chemical 2,3-Dichloropropylene 
5.05      
 50 1045 391 0.374 7.82 26.5 -3.163 
15.2       
 50 1055 605 0.573 12.10 26.5 48.416 
50.5       
 50 1050 1111 1.058 22.22 26.6 173.844 
152         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1049 711 0.678 14.22 26.5 75.418
Mitomycin-C 
 0.01      
 10 210 241 1.148 24.10 26.5 197.014
Trend: 20.858        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/04/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1021 356 0.349 7.12 26.0 0.000
Test Chemical 2,3-Dichloropropylene 
9.95      
 50 1049 541 0.516 10.82 26.0 47.910 
29.9       
 50 1052 839 0.798 16.78 26.0 128.729 
49.8       
 50 1060 1111 1.048 22.22 30.0 200.597 
74.5       
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1033 510 0.494 10.20 26.0 41.594
Mitomycin-C 
 0.01      
 10 209 201 0.962 20.10 26.0 175.820
Trend: 20.734        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/14/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 482 0.463 9.64 26.0 0.000
Test Chemical 2,3-Dichloropropylene 
5.05      
 50 1040 451 0.434 9.02 26.0 -6.432 
15.2       
 50 1038 492 0.474 9.84 26.0 2.271 
50.5       
 50 1042 789 0.757 15.78 26.0 63.379 
152         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1044 690 0.661 13.80 26.0 42.605
Cyclophosphamide 
2.5       
 10 210 329 1.567 32.90 26.0 238.036
Trend: 9.227        
Probability: 0.000