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Study Information
Study Attribute Value
CEBS Accession Number: 002-01190-0002-0000-5
Chemical Name: 2,3-Dichloropropylene
CASRN: 78-88-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 850916_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 01/16/1986    Harvest Time: 10.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 10 0.050 5.0 0 0.000 0.0 10 0.050 5.0 0 0.000 0.0
Test Chemical: 2,3-Dichloropropylene 
13.3       
 200 11 0.055 5.0 2 0.010 1.0 9 0.045 4.0 0 0.000 0.0 
39.9       
 200 22 0.110 10.0 1 0.005 1.0 21 0.105 10.0 0 0.000 0.0 
133         
 200 59 0.295 24.0 1 0.005 1.0 57 0.285 23.0 1 0.005 1.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 100 50 0.500 40.0 12 0.120 12.0 38 0.380 31.0 0 0.000 0.0
Mitomycin-C 
5         
 50 57 1.140 58.0 12 0.240 20.0 35 0.700 46.0 10 0.200 1.0
Trend: 6.448 1.043 6.379  
Probability: 0.000 0.148 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/16/1986    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: 2,3-Dichloropropylene 
13.3       
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 2.0 0 0.000 0.0 
39.9       
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
133         
 200 30 0.150 12.0 1 0.005 1.0 29 0.145 12.0 0 0.000 0.0 
200         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 51 1.020 56.0 9 0.180 18.0 22 0.440 38.0 20 0.400 2.0
Trend: 4.224 0.880 4.224  
Probability: 0.000 0.189 0.000  


Trial #:2   Activation: No Activation    Date: 01/30/1986    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 2.0 2 0.010 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: 2,3-Dichloropropylene 
50.5       
 50 130 2.600 46.0 12 0.240 14.0 28 0.560 22.0 90 1.800 9.0 
75.5       
 50 298 5.960 80.0 7 0.140 10.0 41 0.820 30.0 250 5.000 25.0 
101         
 50 353 7.060 92.0 16 0.320 24.0 47 0.940 26.0 290 5.800 29.0 
151         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.2       
 100 75 0.750 39.0 30 0.300 24.0 23 0.230 18.0 22 0.220 4.0
Mitomycin-C 
5         
 15 134 8.933 100.0 5 0.333 20.0 9 0.600 20.0 120 8.000 12.0
Trend: 14.740 5.494 6.728  
Probability: 0.000 0.000 0.000