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Study Information
Study Attribute Value
CEBS Accession Number: 002-01204-0001-0000-0
Chemical Name: 2,4,5-Trimethoxybenzaldehyde
CASRN: 4460-86-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 882349_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/19/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 410 0.393 8.20 26.5 0.000
Test Chemical 2,4,5-Trimethoxybenzaldehyde 
1.6       
 50 1020 444 0.435 8.88 26.5 10.841 
5         
 50 1042 461 0.442 9.22 26.5 12.655 
16         
 50 1044 498 0.477 9.96 26.5 21.463 
50         
 50 1047 536 0.512 10.72 26.5 30.357 
160         
 0 0 0 0.000 0.00 26.5 N/A 
500         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1042 563 0.540 11.26 26.5 37.581
Mitomycin-C 
 0.01      
 10 210 388 1.848 38.80 26.5 370.467
Trend: 4.260        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/02/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 419 0.400 8.38 26.0 0.000
Test Chemical 2,4,5-Trimethoxybenzaldehyde 
16         
 50 1046 462 0.442 9.24 26.0 10.368 
50         
 50 1048 518 0.494 10.36 26.0 23.510 
75         
 50 1048 652 0.622 13.04 26.0 55.460 
100         
 50 1049 657 0.626 13.14 26.0 56.503 
200         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 561 0.534 11.22 26.0 33.508
Mitomycin-C 
 0.005     
 10 210 250 1.190 25.00 26.0 197.477
Trend: 8.796        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/19/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 395 0.381 7.90 26.0 0.000
Test Chemical 2,4,5-Trimethoxybenzaldehyde 
50         
 50 1041 437 0.420 8.74 26.0 10.102 
160         
 50 1049 397 0.378 7.94 26.0 -0.739 
500         
 50 1039 384 0.370 7.68 26.0 -3.066 
1600         
 50 1024 461 0.450 9.22 26.0 18.077
Positive Control Cyclophosphamide 
 0.3       
 50 1046 579 0.554 11.58 26.0 45.181
Cyclophosphamide 
2         
 10 210 314 1.495 31.40 26.0 292.169
Trend: 1.394        
Probability: 0.082        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/28/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 429 0.411 8.58 26.0 0.000
Test Chemical 2,4,5-Trimethoxybenzaldehyde 
500         
 50 1042 430 0.413 8.60 26.0 0.425 
750         
 50 1041 401 0.385 8.02 26.0 -6.257 
1000         
 50 1032 390 0.378 7.80 26.0 -8.034 
1500         
 50 1050 429 0.409 8.58 26.0 -0.571
Positive Control Cyclophosphamide 
 0.3       
 50 1050 620 0.590 12.40 26.0 43.696
Trend: -0.625        
Probability: 0.734