COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01205-0001-0000-1
Chemical Name: 2,4,5-Trimethylaniline
CASRN: 137-17-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 005305_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/10/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 344 0.330 6.88 26.5 0.000
Test Chemical 2,4,5-Trimethylaniline 
8.1       
 50 1048 393 0.375 7.86 26.5 13.590 
25.3       
 50 1048 412 0.393 8.24 26.5 19.082 
81         
 50 1042 458 0.440 9.16 26.5 33.140 
253         
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1037 547 0.527 10.94 26.5 59.778
Mitomycin-C 
 0.01      
 10 207 210 1.014 21.00 26.5 207.297
Trend: 4.034        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/15/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 378 0.362 7.56 27.0 0.000
Test Chemical 2,4,5-Trimethylaniline 
108         
 50 1048 535 0.510 10.70 27.0 40.859 
135         
 50 1038 514 0.495 10.28 27.0 36.634 
162         
 50 1047 570 0.544 11.40 27.0 50.218 
269         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1049 521 0.497 10.42 27.0 37.042
Mitomycin-C 
 0.01      
 10 208 181 0.870 18.10 27.0 140.109
Trend: 5.812        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 10/15/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 378 0.362 7.56 27.0 0.000
Test Chemical 2,4,5-Trimethylaniline 
215         
 50 1044 391 0.375 7.82 27.0 3.340 
430         
 50 1032 481 0.466 9.62 27.0 28.605 
645         
 50 1049 486 0.463 9.72 27.0 27.836 
860         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1049 521 0.497 10.42 27.0 37.042
Mitomycin-C 
 0.01      
 10 208 181 0.870 18.10 27.0 140.109
Trend: 4.583        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/10/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 382 0.367 7.64 26.0 0.000
Test Chemical 2,4,5-Trimethylaniline 
81         
 50 1049 465 0.443 9.30 26.0 20.799 
253         
 50 1047 509 0.486 10.18 26.0 32.482 
810         
 50 1048 718 0.685 14.36 30.0 86.703 
1220         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1046 604 0.577 12.08 26.0 57.359
Cyclophosphamide 
2.5       
 10 207 248 1.198 24.80 26.0 226.489
Trend: 10.342        
Probability: 0.000