Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01205-0002-0000-2 |
Chemical Name: | 2,4,5-Trimethylaniline |
CASRN: | 137-17-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 005305_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
No Activation | 2 | Negative |
No Activation | 3 | Weakly Positive* |
No Activation | 4 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4,5-Trimethylaniline | 755 | 200 | 65 | 0.325 | 12.5 | 18 | 0.090 | 6.0 | 27 | 0.135 | 9.0 | 20 | 0.100 | 2.0 |
865 | 200 | 24 | 0.120 | 7.0 | 11 | 0.055 | 5.0 | 13 | 0.065 | 3.5 | 0 | 0.000 | 0.0 | ||
1080 | 200 | 86 | 0.430 | 22.0 | 20 | 0.100 | 7.5 | 46 | 0.230 | 15.5 | 20 | 0.100 | 2.0 | ||
Positive Control: | Mitomycin-C | 0.2 | 200 | 30 | 0.150 | 12.0 | 9 | 0.045 | 4.0 | 20 | 0.100 | 8.5 | 1 | 0.005 | 1.0 |
Mitomycin-C | 5 | 10 | 65 | 6.500 | 100.0 | 6 | 0.600 | 30.0 | 9 | 0.900 | 40.0 | 50 | 5.000 | 5.0 | |
Trend: | 6.573 | 3.275 | 5.397 | ||||||||||||
Probability: | 0.000 | 0.001 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4,5-Trimethylaniline | 47.1 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 1 | 0.005 | 1.0 |
142 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
471 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
940 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 24 | 0.480 | 36.0 | 11 | 0.220 | 20.0 | 12 | 0.240 | 18.0 | 1 | 0.020 | 1.0 |
Trend: | 0.690 | -1.840 | 1.905 | ||||||||||||
Probability: | 0.245 | 0.967 | 0.028 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4,5-Trimethylaniline | 47.1 | 200 | 8 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 8 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
142 | 200 | 8 | 0.040 | 3.5 | 0 | 0.000 | 0.0 | 8 | 0.040 | 3.5 | 0 | 0.000 | 0.0 | ||
471 | 200 | 13 | 0.065 | 6.0 | 1 | 0.005 | 0.5 | 12 | 0.060 | 5.5 | 0 | 0.000 | 0.0 | ||
940 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 1 | 200 | 82 | 0.410 | 27.0 | 22 | 0.110 | 10.0 | 50 | 0.250 | 20.5 | 10 | 0.050 | 1.0 |
Mitomycin-C | 5 | 10 | 14 | 1.400 | 80.0 | 8 | 0.800 | 60.0 | 5 | 0.500 | 40.0 | 1 | 0.100 | 1.0 | |
Trend: | 1.889 | 1.382 | 1.662 | ||||||||||||
Probability: | 0.029 | 0.084 | 0.048 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4,5-Trimethylaniline | 104 | 200 | 7 | 0.035 | 3.5 | 2 | 0.010 | 1.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
207 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
620 | 72 | 48 | 0.667 | 26.4 | 4 | 0.056 | 4.2 | 24 | 0.333 | 20.8 | 20 | 0.278 | 2.0 | ||
830 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.2 | 200 | 31 | 0.155 | 12.5 | 5 | 0.025 | 2.5 | 25 | 0.125 | 10.0 | 1 | 0.005 | 1.0 |
Mitomycin-C | 5 | 10 | 84 | 8.400 | 100.0 | 2 | 0.200 | 10.0 | 2 | 0.200 | 20.0 | 80 | 8.000 | 8.0 | |
Trend: | 6.590 | 1.899 | 6.041 | ||||||||||||
Probability: | 0.000 | 0.029 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4,5-Trimethylaniline | 415 | 200 | 103 | 0.515 | 6.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 100 | 0.500 | 10.0 |
620 | 200 | 61 | 0.305 | 6.0 | 7 | 0.035 | 2.0 | 4 | 0.020 | 1.5 | 50 | 0.250 | 5.0 | ||
830 | 47 | 110 | 2.340 | 57.4 | 5 | 0.106 | 8.5 | 25 | 0.532 | 38.3 | 80 | 1.702 | 8.0 | ||
1040 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.2 | 200 | 31 | 0.155 | 12.5 | 5 | 0.025 | 2.5 | 25 | 0.125 | 10.0 | 1 | 0.005 | 1.0 |
Mitomycin-C | 5 | 10 | 84 | 8.400 | 100.0 | 2 | 0.200 | 10.0 | 2 | 0.200 | 20.0 | 80 | 8.000 | 8.0 | |
Trend: | 7.837 | 2.963 | 7.082 | ||||||||||||
Probability: | 0.000 | 0.002 | 0.000 |