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Study Information
Study Attribute Value
CEBS Accession Number: 002-01209-0001-0000-5
Chemical Name: 2,4,6-Trichlorophenol
CASRN: 88-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 815997_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/11/1981    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1046 450 0.430 9.00 26.0 0.000
Test Chemical 2,4,6-Trichlorophenol
5         
50 1050 474 0.451 9.48 26.0 4.932
16         
50 1047 521 0.498 10.42 26.0 15.667
50         
50 1046 457 0.437 9.14 26.0 1.556
Positive Control Triethylenemelamine
 0.015     
50 1047 1332 1.272 26.64 26.0 195.717
Trend: 0.720        
Probability: 0.236        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/11/1981    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1046 454 0.434 9.08 26.0 0.000
Test Chemical 2,4,6-Trichlorophenol
16         
50 1048 478 0.456 9.56 26.0 5.085
50         
50 1044 483 0.463 9.66 26.0 6.591
160         
50 1044 468 0.448 9.36 26.0 3.281
500         
50 1046 486 0.465 9.72 26.0 7.048
Positive Control Cyclophosphamide
1         
50 1047 994 0.949 19.88 26.0 118.734
Trend: 0.809        
Probability: 0.209