Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01209-0001-0000-5 |
Chemical Name: | 2,4,6-Trichlorophenol |
CASRN: | 88-06-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 815997_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 450 | 0.430 | 9.00 | 26.0 | 0.000 |
Test Chemical | 2,4,6-Trichlorophenol | 5 | 50 | 1050 | 474 | 0.451 | 9.48 | 26.0 | 4.932 |
16 | 50 | 1047 | 521 | 0.498 | 10.42 | 26.0 | 15.667 | ||
50 | 50 | 1046 | 457 | 0.437 | 9.14 | 26.0 | 1.556 | ||
Positive Control | Triethylenemelamine | 0.015 | 50 | 1047 | 1332 | 1.272 | 26.64 | 26.0 | 195.717 |
Trend: | 0.720 | ||||||||
Probability: | 0.236 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1046 | 454 | 0.434 | 9.08 | 26.0 | 0.000 |
Test Chemical | 2,4,6-Trichlorophenol | 16 | 50 | 1048 | 478 | 0.456 | 9.56 | 26.0 | 5.085 |
50 | 50 | 1044 | 483 | 0.463 | 9.66 | 26.0 | 6.591 | ||
160 | 50 | 1044 | 468 | 0.448 | 9.36 | 26.0 | 3.281 | ||
500 | 50 | 1046 | 486 | 0.465 | 9.72 | 26.0 | 7.048 | ||
Positive Control | Cyclophosphamide | 1 | 50 | 1047 | 994 | 0.949 | 19.88 | 26.0 | 118.734 |
Trend: | 0.809 | ||||||||
Probability: | 0.209 |