Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01209-0002-0000-6 |
Chemical Name: | 2,4,6-Trichlorophenol |
CASRN: | 88-06-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 815997_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4,6-Trichlorophenol | 50 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
160 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Triethylenemelamine | 0.15 | 100 | 27 | 0.270 | 23.0 | 7 | 0.070 | 7.0 | 20 | 0.200 | 18.0 | 0 | 0.000 | 0.0 |
Trend: | 0.957 | -0.450 | 1.146 | ||||||||||||
Probability: | 0.169 | 0.674 | 0.126 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4,6-Trichlorophenol | 50 | 100 | 9 | 0.090 | 6.0 | 1 | 0.010 | 1.0 | 8 | 0.080 | 5.0 | 0 | 0.000 | 0.0 |
160 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 28 | 0.280 | 24.0 | 9 | 0.090 | 8.0 | 19 | 0.190 | 18.0 | 0 | 0.000 | 0.0 |
Trend: | 0.329 | 0.630 | 0.116 | ||||||||||||
Probability: | 0.371 | 0.264 | 0.454 |