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Study Information
Study Attribute Value
CEBS Accession Number: 002-01209-0002-0000-6
Chemical Name: 2,4,6-Trichlorophenol
CASRN: 88-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 815997_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/11/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2,4,6-Trichlorophenol
50         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
160         
100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
500         
100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Triethylenemelamine
 0.15      
100 27 0.270 23.0 7 0.070 7.0 20 0.200 18.0 0 0.000 0.0
Trend: 0.957 -0.450 1.146  
Probability: 0.169 0.674 0.126  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/11/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 2,4,6-Trichlorophenol
50         
100 9 0.090 6.0 1 0.010 1.0 8 0.080 5.0 0 0.000 0.0
160         
100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
500         
100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 28 0.280 24.0 9 0.090 8.0 19 0.190 18.0 0 0.000 0.0
Trend: 0.329 0.630 0.116  
Probability: 0.371 0.264 0.454