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Study Information
Study Attribute Value
CEBS Accession Number: 002-01209-0009-0000-3
Chemical Name: 2,4,6-Trichlorophenol
CASRN: 88-06-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 736391
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 78 92 60 26 31
    74 92 106 48
    89 101 55 21
    82 115 70 28
Test Chemical 2,4,6-Trichlorophenol 
6.25      
 97 89 130 45 36
    86 94 68 27
  
12.5       
 67 78 70 35 27
    69 81 41 20
  
25         
 66 79 94 48 42
    83# 73 90 36
  
50         
 78 66 98 42 42
    73 70 91 42
  
100         
 48 11 122 85 75*
    60 10 119 66
  
200         
   
Positive Control Methyl Methane Sulfonate 
15         
 48 40 163 114 102*
    43 40 116 91
Methyl Methane Sulfonate 
250         
 63 99 280 149 142*
    64 75 255 134

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 97 96 129 45 41
    114 90 141 41
    92 100 106 38
    109 115 126 39
Test Chemical 2,4,6-Trichlorophenol 
10         
 92 106 141 51 51
    104 89 159 51
  
20         
 76 88 114 50 58
    80 87 155 65
  
40         
 84 68 174 69 60
    99 74 154 52
  
80         
 79 26 199 85 81*
    91 19 212 78
  
120         
 93 11 385 138 185*
    71 9 496 233
  
160         
   
Positive Control Methyl Methane Sulfonate 
15         
 38 25 207 183 173*
    45 31 219 162
Methyl Methane Sulfonate 
250         
 64 70 455 236 237*
    56 71 403 238

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination