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Study Information
Study Attribute Value
CEBS Accession Number: 002-01212-0002-0000-0
Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: 26471-62-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 161856_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/21/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2,4- & 2,6-Toluene diisocyanate 
300         
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 0.5 0 0.000 0.0 
500         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
1000         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 49 0.245 22.0 17 0.085 8.0 32 0.160 15.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 17 0.340 28.0 8 0.160 14.0 9 0.180 18.0 0 0.000 0.0
Trend: 0.555 0.000 0.555  
Probability: 0.289 0.000 0.289  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/21/1986    Harvest Time: 13.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,4- & 2,6-Toluene diisocyanate 
300         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
500         
 200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0 
1000         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 29 0.145 13.5 8 0.040 4.0 21 0.105 9.5 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 23 0.460 36.0 8 0.160 14.0 15 0.300 26.0 0 0.000 0.0
Trend: 0.441 0.608 -0.049  
Probability: 0.330 0.272 0.519