Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01212-0002-0000-0 |
Chemical Name: | 2,4- & 2,6-Toluene diisocyanate |
CASRN: | 26471-62-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 161856_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4- & 2,6-Toluene diisocyanate | 300 | 200 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 |
500 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 49 | 0.245 | 22.0 | 17 | 0.085 | 8.0 | 32 | 0.160 | 15.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 17 | 0.340 | 28.0 | 8 | 0.160 | 14.0 | 9 | 0.180 | 18.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.555 | 0.000 | 0.555 | ||||||||||||
Probability: | 0.289 | 0.000 | 0.289 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2,4- & 2,6-Toluene diisocyanate | 300 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
500 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
1000 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 29 | 0.145 | 13.5 | 8 | 0.040 | 4.0 | 21 | 0.105 | 9.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 23 | 0.460 | 36.0 | 8 | 0.160 | 14.0 | 15 | 0.300 | 26.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.441 | 0.608 | -0.049 | ||||||||||||
Probability: | 0.330 | 0.272 | 0.519 |