Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01212-0010-0000-9
Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: 26471-62-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 544551_SCE
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/20/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.92 ± 0.203
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
25         
 4 8.68 ± 1.030
  
50         
 4 8.21 ± 0.309
  
100         
 4 7.63 ± 0.581
Positive Control Dimethylbenzanthracene 
2.5       
 4 19.18 ± 0.690


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/14/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.49 ± 0.365
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
12.5       
 4 6.08 ± 0.529
  
25         
 4 5.74 ± 0.339
  
50         
 4 5.23 ± 0.522
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.81 ± 1.140


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed