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Study Information
Study Attribute Value
CEBS Accession Number: 002-01212-0010-0000-9
Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: 26471-62-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 544551_SCE
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/20/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.92 ± 0.203
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
25         
 4 8.68 ± 1.030
  
50         
 4 8.21 ± 0.309
  
100         
 4 7.63 ± 0.581
Positive Control Dimethylbenzanthracene 
2.5       
 4 19.18 ± 0.690


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/14/89 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.49 ± 0.365
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
12.5       
 4 6.08 ± 0.529
  
25         
 4 5.74 ± 0.339
  
50         
 4 5.23 ± 0.522
Positive Control Dimethylbenzanthracene 
2.5       
 4 12.81 ± 1.140


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed