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Study Information
Study Attribute Value
CEBS Accession Number: 002-01212-0011-0000-0
Chemical Name: 2,4- & 2,6-Toluene diisocyanate
CASRN: 26471-62-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 544551_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/29/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.2714
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 9.50 ± 1.24 0.0000
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
25         
 8 1.25 ± 0.65 0.5000
  
50         
 8 0.75 ± 0.37 0.7614
  
100         
 8 1.75 ± 0.59 0.2804
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/11/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.7937
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
25         
 7 15.43 ± 2.38 0.0000
Test Chemical 2,4- & 2,6-Toluene diisocyanate 
25         
 8 0.50 ± 0.33 0.9719
  
50         
 8 1.25 ± 0.37 0.7992
  
100         
 8 1.00 ± 0.38 0.8777
Vehicle Control No Stressor 
 0         
 8 2.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed