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Study Information
Study Attribute Value
CEBS Accession Number: 002-01215-0001-0000-2
Chemical Name: 2,4-Diaminoanisole sulfate
CASRN: 39156-41-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 455103_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/07/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1047 360 0.344 7.20 25.5 0.000
Test Chemical 2,4-Diaminoanisole sulfate 
7.5       
 50 1048 415 0.396 8.30 25.5 15.168 
25         
 50 1050 827 0.788 16.54 25.5 129.066 
75         
 50 1039 1452 1.397 29.04 33.5 306.439 
250         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 583 0.555 11.66 25.5 61.482
Mitomycin-C 
 0.01      
 5 105 214 2.038 42.80 25.5 492.746
Trend: 29.874        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/20/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 25 525 179 0.341 7.16 25.4 0.000
Test Chemical 2,4-Diaminoanisole sulfate 
18.9       
 25 525 238 0.453 9.52 25.4 32.961 
25.1       
 25 522 261 0.500 10.44 25.4 46.648 
62.8       
 25 518 515 0.994 20.60 25.4 191.597 
125.6       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 524 296 0.565 11.84 25.4 65.679
Mitomycin-C 
 0.01      
 5 104 183 1.760 36.60 25.4 416.088
Trend: 14.469        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/07/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 327 0.312 6.54 25.5 0.000
Test Chemical 2,4-Diaminoanisole sulfate 
75         
 50 1047 570 0.544 11.40 25.5 74.645 
250         
 50 1049 773 0.737 15.46 25.5 136.391 
750         
 50 1040 1444 1.388 28.88 33.5 345.412
Positive Control Cyclophosphamide 
 0.4       
 50 1048 597 0.570 11.94 25.5 82.743
Cyclophosphamide 
2         
 5 105 188 1.790 37.60 25.5 474.376
Trend: 28.509        
Probability: 0.000