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Study Information
Study Attribute Value
CEBS Accession Number: 002-01215-0002-0000-3
Chemical Name: 2,4-Diaminoanisole sulfate
CASRN: 39156-41-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 455103_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/18/1986    Harvest Time: 10.2 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,4-Diaminoanisole sulfate 
126.3       
 100 20 0.200 17.0 7 0.070 6.0 12 0.120 11.0 1 0.010 1.0 
188.5       
 100 45 0.450 31.0 10 0.100 10.0 34 0.340 25.0 1 0.010 1.0 
251.3       
 10 9 0.900 80.0 1 0.100 10.0 7 0.700 70.0 1 0.100 10.0
Positive Control: Mitomycin-C 
 0.25      
 100 12 0.120 12.0 5 0.050 5.0 7 0.070 7.0 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 17 0.680 56.0 6 0.240 20.0 11 0.440 40.0 0 0.000 0.0
Trend: 7.183 3.106 6.685  
Probability: 0.000 0.001 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/27/1986    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 1.5 1 0.005 0.5 1 0.005 0.5 1 0.005 0.5
Medium 
0         
 200 6 0.030 2.0 3 0.015 1.5 3 0.015 0.5 0 0.000 0.0
Test Chemical: 2,4-Diaminoanisole sulfate 
376.9       
 200 5 0.025 2.0 1 0.005 0.5 3 0.015 1.0 1 0.005 0.5 
562.5       
 200 8 0.040 3.5 6 0.030 2.5 1 0.005 0.5 1 0.005 0.5 
750         
 50 61 1.220 34.0 18 0.360 20.0 11 0.220 10.0 32 0.640 10.0
Positive Control: Cyclophosphamide 
6.25      
 200 34 0.170 14.0 16 0.080 6.5 18 0.090 7.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 16 0.640 44.0 8 0.320 32.0 8 0.320 12.0 0 0.000 0.0
Trend: 5.758 4.431 2.808  
Probability: 0.000 0.000 0.002  


Trial #:2   Activation: No Activation    Date: 08/27/1986    Harvest Time: 10.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Medium 
0         
 200 6 0.030 2.5 3 0.015 1.5 3 0.015 1.0 0 0.000 0.0
Test Chemical: 2,4-Diaminoanisole sulfate 
125.6       
 200 56 0.280 20.0 9 0.045 3.5 45 0.225 16.0 2 0.010 1.0 
187.5       
 75 30 0.400 28.0 6 0.080 8.0 23 0.307 20.0 1 0.013 1.3 
250         
 10 12 1.200 80.0 0 0.000 0.0 11 1.100 70.0 1 0.100 10.0
Positive Control: Mitomycin-C 
 0.25      
 200 34 0.170 15.5 18 0.090 9.0 16 0.080 7.5 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 18 0.720 56.0 6 0.240 16.0 11 0.440 36.0 1 0.040 4.0
Trend: 7.662 2.191 6.983  
Probability: 0.000 0.014 0.000