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Study Information
Study Attribute Value
CEBS Accession Number: 002-01216-0001-0000-3
Chemical Name: 2,4-Diaminophenol dihydrochloride
CASRN: 137-09-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 729737_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/13/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1049 490 0.467 9.80 26.0 0.000
Test Chemical 2,4-Diaminophenol dihydrochloride 
 0.09      
 50 1047 431 0.412 8.62 26.0 -11.873 
 0.27      
 50 1049 359 0.342 7.18 26.0 -26.735 
 0.9       
 50 1049 427 0.407 8.54 26.0 -12.857
Positive Control Mitomycin-C 
 0.005     
 25 524 600 1.145 24.00 26.0 145.132
Trend: -2.778        
Probability: 0.997        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/13/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 431 0.411 8.62 26.0 0.000
Test Chemical 2,4-Diaminophenol dihydrochloride 
 0.9       
 50 1046 430 0.411 8.60 26.0 -0.041 
2.7       
 50 1050 435 0.414 8.70 26.0 0.736 
9         
 50 1047 493 0.471 9.86 26.0 14.494
Positive Control Cyclophosphamide 
1         
 25 522 586 1.123 23.44 26.0 172.968
Trend: 2.037        
Probability: 0.021