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Study Information
Study Attribute Value
CEBS Accession Number: 002-01216-0002-0000-4
Chemical Name: 2,4-Diaminophenol dihydrochloride
CASRN: 137-09-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 729737_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/13/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0
Test Chemical: 2,4-Diaminophenol dihydrochloride 
 0.27      
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0 
 0.9       
 100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0 
2.7       
 100 7 0.070 6.0 4 0.040 3.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 30 0.300 25.0 10 0.100 10.0 20 0.200 16.0 0 0.000 0.0
Trend: 1.244 2.304 0.359  
Probability: 0.107 0.011 0.360  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/13/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: 2,4-Diaminophenol dihydrochloride 
 0.9       
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
2.7       
 100 7 0.070 7.0 0 0.000 0.0 7 0.070 7.0 0 0.000 0.0 
9         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 29 0.290 26.0 11 0.110 9.0 18 0.180 17.0 0 0.000 0.0
Trend: 0.890 -0.439 1.012  
Probability: 0.187 0.670 0.156