Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01217-0001-0000-4 |
Chemical Name: | 2,4-Diaminotoluene (2,4-toluene diamine) |
CASRN: | 95-80-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 314882_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1040 | 467 | 0.449 | 9.34 | 27.0 | 0.000 |
Test Chemical | 2,4-Diaminotoluene (2,4-toluene diamine) | 4.68 | 50 | 1046 | 532 | 0.509 | 10.64 | 27.0 | 13.265 |
14.1 | 50 | 1037 | 605 | 0.583 | 12.10 | 27.0 | 29.925 | ||
46.8 | 50 | 1035 | 970 | 0.937 | 19.40 | 31.0 | 108.712 | ||
141 | 0 | 0 | 0 | 0.000 | 0.00 | 31.0 | N/A | ||
Positive Control | Mitomycin-C | 0.002 | 50 | 1047 | 590 | 0.564 | 11.80 | 27.0 | 25.494 |
Mitomycin-C | 0.01 | 10 | 208 | 194 | 0.933 | 19.40 | 27.0 | 107.709 | |
Trend: | 14.188 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1043 | 481 | 0.461 | 9.62 | 26.5 | 0.000 |
Test Chemical | 2,4-Diaminotoluene (2,4-toluene diamine) | 64.5 | 50 | 1040 | 777 | 0.747 | 15.54 | 26.5 | 62.004 |
97 | 50 | 1037 | 1004 | 0.968 | 20.08 | 30.5 | 109.940 | ||
130 | 50 | 1048 | 1288 | 1.229 | 25.76 | 30.5 | 166.498 | ||
194 | 0 | 0 | 0 | 0.000 | 0.00 | 30.5 | N/A | ||
Positive Control | Mitomycin-C | 0.002 | 50 | 1049 | 614 | 0.585 | 12.28 | 26.5 | 26.921 |
Mitomycin-C | 0.01 | 10 | 210 | 258 | 1.229 | 25.80 | 26.5 | 166.403 | |
Trend: | 19.718 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1048 | 455 | 0.434 | 9.10 | 26.0 | 0.000 |
Test Chemical | 2,4-Diaminotoluene (2,4-toluene diamine) | 468 | 50 | 1039 | 728 | 0.701 | 14.56 | 26.0 | 61.386 |
1410 | 50 | 1045 | 571 | 0.546 | 11.42 | 26.0 | 25.855 | ||
4680 | 50 | 1046 | 614 | 0.587 | 12.28 | 26.0 | 35.203 | ||
Positive Control | Cyclophosphamide | 0.5 | 50 | 1052 | 770 | 0.732 | 15.40 | 26.0 | 68.587 |
Cyclophosphamide | 2.5 | 10 | 212 | 279 | 1.316 | 27.90 | 26.0 | 203.123 | |
Trend: | 2.967 | ||||||||
Probability: | 0.002 |