Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01221-0001-0000-9 |
Chemical Name: | 2,4-Dichloronitrobenzene |
CASRN: | 611-06-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 345631_SCE |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1036 | 390 | 0.376 | 7.80 | 26.0 | 0.000 |
Test Chemical | 2,4-Dichloronitrobenzene | 5 | 50 | 1033 | 368 | 0.356 | 7.36 | 26.0 | -5.367 |
16.7 | 50 | 1039 | 387 | 0.372 | 7.74 | 26.0 | -1.056 | ||
50 | 50 | 1025 | 419 | 0.409 | 8.38 | 26.0 | 8.589 | ||
167 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1045 | 611 | 0.585 | 12.22 | 26.0 | 55.317 |
Mitomycin-C | 0.01 | 5 | 106 | 238 | 2.245 | 47.60 | 26.0 | 496.439 | |
Trend: | 1.297 | ||||||||
Probability: | 0.097 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1042 | 392 | 0.376 | 7.84 | 26.0 | 0.000 |
Test Chemical | 2,4-Dichloronitrobenzene | 16.7 | 50 | 1027 | 381 | 0.371 | 7.62 | 26.0 | -1.387 |
50 | 50 | 1033 | 405 | 0.392 | 8.10 | 26.0 | 4.216 | ||
167 | 50 | 1026 | 443 | 0.432 | 8.86 | 26.0 | 14.773 | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.4 | 50 | 1036 | 640 | 0.618 | 12.80 | 26.0 | 64.211 |
Cyclophosphamide | 2 | 5 | 105 | 174 | 1.657 | 34.80 | 26.0 | 340.496 | |
Trend: | 2.163 | ||||||||
Probability: | 0.015 |