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Study Information
Study Attribute Value
CEBS Accession Number: 002-01221-0001-0000-9
Chemical Name: 2,4-Dichloronitrobenzene
CASRN: 611-06-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 345631_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/07/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1036 390 0.376 7.80 26.0 0.000
Test Chemical 2,4-Dichloronitrobenzene
5         
50 1033 368 0.356 7.36 26.0 -5.367
16.7       
50 1039 387 0.372 7.74 26.0 -1.056
50         
50 1025 419 0.409 8.38 26.0 8.589
167         
0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1045 611 0.585 12.22 26.0 55.317
Mitomycin-C
 0.01      
5 106 238 2.245 47.60 26.0 496.439
Trend: 1.297        
Probability: 0.097        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/01/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1042 392 0.376 7.84 26.0 0.000
Test Chemical 2,4-Dichloronitrobenzene
16.7       
50 1027 381 0.371 7.62 26.0 -1.387
50         
50 1033 405 0.392 8.10 26.0 4.216
167         
50 1026 443 0.432 8.86 26.0 14.773
500         
0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide
 0.4       
50 1036 640 0.618 12.80 26.0 64.211
Cyclophosphamide
2         
5 105 174 1.657 34.80 26.0 340.496
Trend: 2.163        
Probability: 0.015