COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01222-0001-0000-0
Chemical Name: 2,4-Dichlorophenol
CASRN: 120-83-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 884240_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Questionable 
No Activation  3  Positive 
No Activation  4  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/08/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1021 550 0.539 11.00 25.5 0.000
Test Chemical 2,4-Dichlorophenol 
 0.167     
 50 1033 588 0.569 11.76 25.5 5.667 
 0.5       
 50 1025 556 0.542 11.12 25.5 0.696 
1.67      
 50 1029 708 0.688 14.16 33.5 27.726 
5         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1034 720 0.696 14.40 25.5 29.263
Mitomycin-C 
 0.01      
 5 104 190 1.827 38.00 25.5 239.143
Trend: 4.012        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/29/1983    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 474 0.457 9.48 25.5 0.000
Test Chemical 2,4-Dichlorophenol 
3         
 50 1038 463 0.446 9.26 25.5 -2.415 
4         
 50 1031 515 0.500 10.30 25.5 9.282 
5         
 50 1033 539 0.522 10.78 25.5 14.153
Positive Control Mitomycin-C 
 0.001     
 50 1041 573 0.550 11.46 25.5 20.422
Mitomycin-C 
 0.01      
 5 103 239 2.320 47.80 25.5 407.646
Trend: 2.580        
Probability: 0.005        

Trial #: 3    Activation: No Activation    Date: 04/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1034 429 0.415 8.58 25.5 0.000
Test Chemical 2,4-Dichlorophenol 
1.6       
 50 1022 566 0.554 11.32 25.5 33.484 
3.1       
 50 1031 606 0.588 12.12 25.5 41.670 
6.3       
 50 1020 603 0.591 12.06 25.5 42.489
Positive Control Mitomycin-C 
 0.001     
 50 1032 724 0.702 14.48 25.5 69.092
Trend: 5.506        
Probability: 0.000        

Trial #: 4    Activation: No Activation    Date: 04/27/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1024 439 0.429 8.78 25.5 0.000
Test Chemical 2,4-Dichlorophenol 
3.1       
 50 1036 524 0.506 10.48 25.5 17.980 
6.3       
 50 1038 559 0.539 11.18 31.5 25.617 
12.6       
 50 1036 590 0.569 11.80 31.5 32.840
Positive Control Mitomycin-C 
 0.001     
 50 1035 710 0.686 14.20 25.5 60.012
Mitomycin-C 
 0.01      
 5 104 231 2.221 46.20 25.5 418.101
Trend: 4.567        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/08/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 552 0.535 11.04 25.5 0.000
Test Chemical 2,4-Dichlorophenol 
50         
 50 1029 595 0.578 11.90 25.5 8.104 
167         
 0 0 0 0.000 0.00 0.0 N/A
Trend: 1.319        
Probability: 0.094        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/29/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 460 0.445 9.20 25.5 0.000
Test Chemical 2,4-Dichlorophenol 
99.7       
 50 1028 477 0.464 9.54 25.5 4.301 
120         
 50 1035 612 0.591 12.24 25.5 32.915 
140.4       
 50 1019 570 0.559 11.40 32.8 25.737 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1032 679 0.658 13.58 25.5 47.895
Cyclophosphamide 
2         
 5 104 208 2.000 41.60 25.5 349.565
Trend: 4.800        
Probability: 0.000