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Study Information
Study Attribute Value
CEBS Accession Number: 002-01222-0002-0000-1
Chemical Name: 2,4-Dichlorophenol
CASRN: 120-83-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 884240_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/04/1983    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2,4-Dichlorophenol 
40.2       
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 2.0 0 0.000 0.0 
50.3       
 100 6 0.060 5.0 4 0.040 4.0 1 0.010 1.0 1 0.010 1.0 
75         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
62.5       
 50 22 0.440 34.0 8 0.160 14.0 14 0.280 22.0 0 0.000 0.0
Trend: 0.868 -0.184 1.399  
Probability: 0.193 0.573 0.081  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/11/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,4-Dichlorophenol 
100.5       
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
125         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
150         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
176         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 50 7 0.140 12.0 4 0.080 6.0 3 0.060 6.0 0 0.000 0.0
Trend: 1.819 0.000 1.289  
Probability: 0.034 0.000 0.099