Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01222-0008-0000-7
Chemical Name:	2,4-Dichlorophenol
CASRN:	120-83-2
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	636821
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	98#	94	85.5	29	28
			77	101	75	32
			93#	107	59	21
			67	98	56	28
Test Chemical	2,4-Dichlorophenol	10	73	66	46	21	29
			52	63	59	38	29
		20	49	53	31	21	27
			56#	34	56	33	27
		40	72#	50	55	25	34
			59#	50	82	46
			86	59	80	31
		50	61	42	84	46	37
			67#	50	56	28	37
		60	62#	31	163	88	69*
			72	41	107	50	69*
Positive Control	Methyl Methane Sulfonate	5	51	39	287	188	192*
			60	41	373	207
			64#	50	348	182

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	87	113	57	22	26
			68	72	62	31
			93	95	90	32
			105	120	64	20
Test Chemical	2,4-Dichlorophenol	20	69	78	57	27	33
			70	80	62	29
			55	56	69	42
		30					99*
			92	29	203	74
			72	16	268	124
		40					163*
			67	7	379	189
			66	7	269	137
		50


Positive Control	Methyl Methane Sulfonate	5	67	49	529	262	271*
			57	41	462	271
			51	33	425	281

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination