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Study Information
Study Attribute Value
CEBS Accession Number: 002-01222-0008-0000-7
Chemical Name: 2,4-Dichlorophenol
CASRN: 120-83-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 636821
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 98# 94 85.5 29 28
    77 101 75 32
    93# 107 59 21
    67 98 56 28
Test Chemical 2,4-Dichlorophenol 
10         
 73 66 46 21 29
    52 63 59 38
  
20         
 49 53 31 21 27
    56# 34 56 33
  
40         
 72# 50 55 25 34
    59# 50 82 46
    86 59 80 31
  
50         
 61 42 84 46 37
    67# 50 56 28
  
60         
 62# 31 163 88 69*
    72 41 107 50
Positive Control Methyl Methane Sulfonate 
5         
 51 39 287 188 192*
    60 41 373 207
    64# 50 348 182

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 87 113 57 22 26
    68 72 62 31
    93 95 90 32
    105 120 64 20
Test Chemical 2,4-Dichlorophenol 
20         
 69 78 57 27 33
    70 80 62 29
    55 56 69 42
  
30         
 99*
    92 29 203 74
    72 16 268 124
  
40         
 163*
    67 7 379 189
    66 7 269 137
  
50         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 67 49 529 262 271*
    57 41 462 271
    51 33 425 281

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination