Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01223-0001-0000-1 |
Chemical Name: | 2,4-Dichlorophenoxyacetic acid |
CASRN: | 94-75-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 079515_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Induced Rat Liver S9 | 2_S9 | Negative |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 25 | 513 | 203 | 0.396 | 8.12 | 25.5 | 0.000 |
Test Chemical | 2,4-Dichlorophenoxyacetic acid | 50 | 50 | 1008 | 448 | 0.444 | 8.96 | 25.5 | 12.315 |
167 | 50 | 1026 | 591 | 0.576 | 11.82 | 25.5 | 45.567 | ||
Positive Control | Mitomycin-C | 0.005 | 10 | 210 | 290 | 1.381 | 29.00 | 25.5 | 248.980 |
Trend: | 5.210 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1020 | 401 | 0.393 | 8.02 | 26.5 | 0.000 |
Test Chemical | 2,4-Dichlorophenoxyacetic acid | 198 | 50 | 1029 | 625 | 0.607 | 12.50 | 32.1 | 54.497 |
248 | 50 | 1026 | 646 | 0.630 | 12.92 | 32.1 | 60.155 | ||
299 | 50 | 1022 | 668 | 0.654 | 13.36 | 32.1 | 66.258 | ||
352 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.005 | 25 | 510 | 589 | 1.155 | 23.56 | 26.5 | 193.766 |
Trend: | 7.545 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1039 | 477 | 0.459 | 9.54 | 25.5 | 0.000 |
Test Chemical | 2,4-Dichlorophenoxyacetic acid | 500 | 50 | 1047 | 494 | 0.472 | 9.88 | 25.5 | 2.773 |
1670 | 50 | 1045 | 497 | 0.476 | 9.94 | 25.5 | 3.595 | ||
5000 | 0 | 0 | 0 | 0.000 | 0.00 | 25.5 | N/A | ||
Positive Control | Cyclophosphamide | 1.5 | 25 | 515 | 688 | 1.336 | 27.52 | 25.5 | 190.990 |
Trend: | 0.547 | ||||||||
Probability: | 0.292 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 382 | 0.364 | 7.64 | 25.5 | 0.000 |
Test Chemical | 2,4-Dichlorophenoxyacetic acid | 3000 | 50 | 1035 | 398 | 0.385 | 7.96 | 25.5 | 5.598 |
3500 | 50 | 1019 | 393 | 0.386 | 7.86 | 25.5 | 5.908 | ||
4200 | 50 | 1036 | 452 | 0.436 | 9.04 | 25.5 | 19.809 | ||
5000 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 1.5 | 50 | 1045 | 1072 | 1.026 | 21.44 | 25.5 | 181.702 |
Trend: | 2.538 | ||||||||
Probability: | 0.006 |